Gut-adipose tissue axis in hepatic fat accumulation in humans

被引:50
|
作者
Munukka, Eveliina [1 ,2 ]
Pekkala, Satu [1 ]
Wiklund, Petri [1 ]
Rasool, Omid [3 ,4 ]
Borra, Ronald [5 ]
Kong, Lingjia [6 ]
Ojanen, Xiaowei [7 ]
Cheng, Shu Mei [1 ]
Roos, Christophe [6 ]
Tuomela, Soile [3 ,4 ]
Alen, Markku [8 ,9 ]
Lahesmaa, Riitta [3 ,4 ]
Cheng, Sulin [1 ,10 ]
机构
[1] Univ Jyvaskyla, Dept Hlth Sci, FI-40014 Jyvaskyla, Finland
[2] Univ Turku, Dept Med Microbiol & Immunol, SF-20500 Turku, Finland
[3] Univ Turku, Turku Ctr Biotechnol, Turku, Finland
[4] Abo Akad Univ, Turku, Finland
[5] Turku Univ Hosp, Dept Diagnost Radiol, FIN-20520 Turku, Finland
[6] Tampere Univ Technol, FIN-33101 Tampere, Finland
[7] Univ Eastern Finland, Dept Appl Phys, Kuopio, Finland
[8] Oulu Univ Hosp, Dept Rehabil Med, Oulu, Finland
[9] Univ Oulu, Inst Hlth Sci, SF-90100 Oulu, Finland
[10] Shanghai Jiao Tong Univ, Dept Phys Educ, Shanghai 200030, Peoples R China
基金
芬兰科学院;
关键词
Faecalibacterium prausnitzii; Microbiota dysbiosis; Adipose tissue inflammation; Leaky gut; LIVER-DISEASE; MICROBIOTA; PROTEIN; INDUCTION; OBESITY; INFLAMMATION; BACTERIA; CELLS; WOMEN;
D O I
10.1016/j.jhep.2014.02.020
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Recent evidence suggests that in animals gut microbiota composition (GMC) affects the onset and progression of hepatic fat accumulation. The aim of this study was to investigate in humans whether subjects with high hepatic fat content (HHFC) differ in their GMC from those with low hepatic fat content (LHFC), and whether these differences are associated with body composition, biomarkers and abdominal adipose tissue inflammation. Methods: Hepatic fat content (HFC) was measured using proton magnetic resonance spectroscopy (H-1 MRS). Fecal GMC was profiled by 16S rRNA fluorescence in situ hybridization and flow cytometry. Adipose tissue gene expression was analyzed using Affymetrix microarrays and quantitative PCR. Results: The HHFC group had unfavorable GMC described by lower amount of Faecalibacterium prausnitzii (FPrau) (p <0.05) and relatively higher Enterobacteria than the LHFC group. Metabolically dysbiotic GMC associated with HOMA-IR and triglycerides (p <0.05 for both). Several inflammation-related adipose tissue genes were differentially expressed and correlated with HFC (p <0.05). In addition, the expression of certain genes correlated with GMC dysbiosis, i.e., low FPrau-to-Bacteroides ratio. Conclusions: HHFC subjects differ unfavorably in their GMC from LHFC subjects. Adipose tissue inflammation may be an important link between GMC, metabolic disturbances, and hepatic fat accumulation. (C)2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:132 / 138
页数:7
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