Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry

被引:119
作者
O'Leary, Claire E. [1 ]
Schneider, Christoph [1 ]
Locksley, Richard M. [1 ,2 ,3 ]
机构
[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
来源
ANNUAL REVIEW OF IMMUNOLOGY, VOL 37, 2019 | 2019年 / 37卷
关键词
tuft cells; POU2F3; type; 2; immunity; IL-25; TRPM5; chemosensation; CHOLINERGIC CHEMOSENSORY CELLS; TASTE RECEPTOR-CELLS; BRUSH CELLS; STEM-CELLS; TYPE-2; IMMUNITY; ALPHA-GUSTDUCIN; BILE-DUCT; BITTER; DOUBLECORTIN; DISTINCT;
D O I
10.1146/annurev-immunol-042718-041505
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Tuft cells-rare solitary chemosensory cells in mucosal epithelia-are undergoing intense scientific scrutiny fueled by recent discovery of unsuspected connections to type 2 immunity. These cells constitute a conduit by which ligands from the external space are sensed via taste-like signaling pathways to generate outputs unique among epithelial cells: the cytokine IL-25, eicosanoids associated with allergic immunity, and the neurotransmitter acetylcholine. The classic type II taste cell transcription factor POU2F3 is lineage defining, suggesting a conceptualization of these cells as widely distributed environmental sensors with effector functions interfacing type 2 immunity and neural circuits. Increasingly refined single-cell analytics have revealed diversity among tuft cells that extends from nasal epithelia and type II taste cells to ex-Aire-expressing medullary thymic cells and small-intestine cells that mediate tissue remodeling in response to colonizing helminths and protists.
引用
收藏
页码:47 / 72
页数:26
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