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Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1β production from human phagocytes
被引:16
作者:
Shim, Jae Woong
[1
]
Jo, Seong Ho
[1
]
Kim, Sang Doo
[1
]
Lee, Ha Young
[1
]
Yun, Jeanho
[1
]
Bae, Yoe-Sik
[1
]
机构:
[1] Dong A Univ, Dept Biochem, Coll Med, Pusan 602714, South Korea
关键词:
cell migration inhibition;
chemotaxis;
leukocyte;
interleukin-1;
beta;
lysophosphatidylglycerol;
phagocytes;
receptors;
formyl peptide;
PROTEIN-COUPLED RECEPTOR;
OVARIAN-CANCER CELLS;
NF-KAPPA-B;
PHOSPHOLIPASE A(2);
RESPIRATORY BURST;
HUMAN NEUTROPHILS;
HUMAN MONOCYTES;
IDENTIFICATION;
FPRL1;
ACID;
D O I:
10.3858/emm.2009.41.8.064
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1 beta production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1 beta production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.
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页码:584 / 591
页数:8
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