Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1β production from human phagocytes

被引：17

作者：

Shim, Jae Woong ^{[1
]}

Jo, Seong Ho ^{[1
]}

Kim, Sang Doo ^{[1
]}

Lee, Ha Young ^{[1
]}

Yun, Jeanho ^{[1
]}

Bae, Yoe-Sik ^{[1
]}

机构：

[1] Dong A Univ, Dept Biochem, Coll Med, Pusan 602714, South Korea

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2009年 / 41卷 / 08期

关键词：

cell migration inhibition; chemotaxis; leukocyte; interleukin-1; beta; lysophosphatidylglycerol; phagocytes; receptors; formyl peptide; PROTEIN-COUPLED RECEPTOR; OVARIAN-CANCER CELLS; NF-KAPPA-B; PHOSPHOLIPASE A(2); RESPIRATORY BURST; HUMAN NEUTROPHILS; HUMAN MONOCYTES; IDENTIFICATION; FPRL1; ACID;

D O I：

10.3858/emm.2009.41.8.064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1 beta production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1 beta production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.

引用

页码：584 / 591

页数：8

共 27 条

[21] Multiple astrocyte responses to lysophosphatidic acids [J].

Steiner, MR ;

Urso, JR ;

Klein, J ;

Steiner, SM .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2002, 1582 (1-3) :154-160

[22] A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells [J].

Su, SB ;

Gong, WH ;

Gao, JL ;

Shen, WP ;

Murphy, PM ;

Oppenheim, JJ ;

Wang, JM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (02) :395-402

[23] Serum amyloid A, the major vertebrate acute-phase reactant [J].

Uhlar, CM ;

Whitehead, AS .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 265 (02) :501-523

[24] IDENTIFICATION OF A PUTATIVE MEMBRANE-RECEPTOR FOR THE BIOACTIVE PHOSPHOLIPID, LYSOPHOSPHATIDIC ACID [J].

VANDERBEND, RL ;

BRUNNER, J ;

JALINK, K ;

VANCORVEN, EJ ;

MOOLENAAR, WH ;

VANBLITTERSWIJK, WJ .

EMBO JOURNAL, 1992, 11 (07) :2495-2501

[25] Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells [J].

Xie, YH ;

Gibbs, TC ;

Mukhin, YV ;

Meier, KE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (36) :32516-32526

[26] LYSOPHOSPHOLIPIDS ACTIVATE OVARIAN AND BREAST-CANCER CELLS [J].

XU, Y ;

FANG, XJ ;

CASEY, G ;

MILLS, GB .

BIOCHEMICAL JOURNAL, 1995, 309 :933-940

[27] LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells [J].

Yang, D ;

Chen, Q ;

Schmidt, AP ;

Anderson, GM ;

Wang, JM ;

Wooters, J ;

Oppenheim, JJ ;

Chertov, O .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (07) :1069-1074

← 1 2 3 →