Protective Effect of Tang Wang One Decoction on the Retinal Vessels of Diabetic Rats

被引：1
|
作者：
Kou, Xinyun [1 ,2 ]
Yang, Shufei [1 ]
Qin, Yali [1 ]
Yang, Chao [1 ]
Deng, Tingting [1 ]
Luo, Dan [1 ]
Jin, Ming [1 ]
机构：
[1] China Japan Friendship Hosp, 2 Yinghua East St, Beijing 100029, Peoples R China
[2] Xicheng Maternal & Child Hlth Hosp, 19 Pingyuan St, Beijing 100054, Peoples R China
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2017年 / 2017卷
基金：
中国国家自然科学基金;
关键词：
ENDOTHELIAL-CELLS; RETINOPATHY; INFLAMMATION; MMP-9;
D O I：
10.1155/2017/8635127
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Objective. This study aimed to determine the influence of Tang Wang One Decoction (TWOD) on the retinal vessels of diabetic rats. Methods. The hemorheology of diabetic rats was observed. Morphological studies of retinal vessels were conducted using optical microscopy and electron microscopy. Immunological histochemistry assay was used to measure the expression levels of MMP-9, occludin, and claudin-5. Results. Obvious pathological damage was observed in the retinal vessels of diabetic rats. TWOD positively affected the hemorheology and morphology of retinal vessels. The decoction also decreased the expression of MMP-9 and increased the expression of occludin and claudin-5. Conclusions. The results suggest that the retinal protective effects of TWOD might be related to downregulation of MMP-9 and upregulation of occludin and claudin-5.
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收藏
页数：11
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