The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones

被引：186
|
作者：
Meek, Claire L. [1 ,2 ]
Lewis, Hannah B. [1 ]
Reimann, Frank [1 ]
Gribble, Fiona M. [1 ]
Park, Adrian J. [1 ,2 ]
机构：
[1] Univ Cambridge, Addenbrookess Hosp, Inst Metab Sci, Metab Res Labs, Box 289,Hills Rd, Cambridge CB2 0QQ, England
[2] Addenbrookes Hosp, Dept Clin Biochem, Hills Rd, Cambridge CB2 0QQ, England
来源：
PEPTIDES | 2016年 / 77卷
基金：
英国惠康基金;
关键词：
Bariatric; Ghrelin; Gastrin; Cholecystokinin; Incretin; Oxyntomodulin; GLUCAGON-LIKE PEPTIDE-1; Y GASTRIC BYPASS; BETA-CELL FUNCTION; LAPAROSCOPIC SLEEVE GASTRECTOMY; DUODENAL-JEJUNAL EXCLUSION; PLASMA GHRELIN LEVELS; INDUCED WEIGHT-LOSS; BODY-WEIGHT; ILEAL TRANSPOSITION; GLUCOSE-METABOLISM;
D O I：
10.1016/j.peptides.2015.08.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bariatric surgery for obesity has proved to be an extremely effective method of promoting long-term weight reduction with additional beneficial metabolic effects, such as improved glucose tolerance and remission of type 2 diabetes. A range of bariatric procedures are in common use, including gastric banding, sleeve gastrectomy and the Roux-en-Y gastric bypass. Although the mechanisms underlying the efficacy of bariatric surgery are unclear, gastrointestinal and pancreatic peptides are thought to play an important role. The aim of this review is to summarise the effects of different bariatric surgery procedures upon gastrointestinal and pancreatic peptides, including ghrelin, gastrin, cholecystokinin (CCK), glucose-dependent insulinotropic hormone (GIP), glucagon-like peptide 1 (GLP-1), peptide YY (PYY), oxyntomodulin, insulin, glucagon and somatostatin. (C) 2015 The Authors. Published by Elsevier Inc.
引用
收藏
页码：28 / 37
页数：10
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