Mild, Redox-Neutral Alkylation of !mines Enabled by an Organic Photocatalyst

被引：155
作者：
Patel, Niki R. [1 ]
Kelly, Christopher B. [1 ]
Siegenfeld, Allison P. [1 ]
Molander, Gary A. [1 ]
机构：
[1] Univ Penn, Roy & Diana Vagelos Labs, Dept Chem, 231 South 34th St, Philadelphia, PA 19104 USA
来源：
ACS CATALYSIS | 2017年 / 7卷 / 03期
关键词：
visible light; photocatalysis; imines; hypervalent silicon; radical alkylation; PHOTOREDOX/NICKEL DUAL CATALYSIS; SINGLE-ELECTRON TRANSMETALATION; RADICAL-ADDITION; NICKEL CATALYSIS; CARBON-CARBON; IMINES; LIGHT; SILICATES; ARYL; POLYMERIZATIONS;
D O I：
10.1021/acscatal.6b03665
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
An operationally simple, mild, redox-neutral method for the photoredox alkylation of imines is reported. Utilizing an inexpensive organic photoredox catalyst, alkyl radicals are readily generated from the single-electron oxidation of ammonium alkyl bis(catecholato)silicates and are subsequently engaged in a C-C bond-forming reaction with imines. The process is highly selective, metal-free, and does not require a large excess of the alkylating reagent or the use of acidic additives.
引用
收藏
页码：1766 / 1770
页数：5
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