Retroviral capsid determinants of Fv1 NB and NR tropism

被引：50
作者：
Stevens, A
Bock, M
Ellis, S
LeTissier, P
Bishop, KN
Yap, MW
Taylor, W
Stoye, JP
机构：
[1] Natl Inst Med Res, Div Virol, London NW7 1AA, England
[2] Natl Inst Med Res, Div Math Biol, London NW7 1AA, England
来源：
JOURNAL OF VIROLOGY | 2004年 / 78卷 / 18期
关键词：
D O I：
10.1128/JVI.78.18.9592-9598.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The specificity determinants for susceptibility to resistance by the Fv1 n and b alleles map to amino acid 110 of the murine leukemia virus CA protein. To study the interaction between Fv1 and CA, we examined changes in CA resulting in the loss of susceptibility to Fv1 resistance in naturally occurring NB- and NR-tropic viruses. A variety of amino acid changes affecting Fv1 tropism were identified, at CA positions 82, 92 to 95, 105, 114, and 117, and they all were mapped to the apparent exterior of virion-associated CA. These amino acids may form a binding surface for Fv1.
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页码：9592 / 9598
页数：7
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