Are Brazilian cervids at risk of prion diseases?

被引：6

作者：

Ribeiro Falcao, Caio Bruno ^{[1
]}

Nunes Freire Lima, Isabel Luiza de Melo ^{[1
]}

Barbanti Duarte, Jose Mauricio ^{[2
]}

Mendes de Oliveira, Joao Ricardo ^{[3
]}

Torres, Rodrigo Augusto ^{[4
]}

Wanderley, Artur Maia ^{[1
]}

Gomes da Cunha, Jose Eriton ^{[3
]}

Garcia, Jose Eduardo ^{[1
]}

机构：

[1] Univ Fed Pernambuco, Ctr Acad Vitoria, Vitoria De Santo Antao, PE, Brazil

[2] Univ Estadual Paulista, Dept Zootecnia, Sao Paulo, Brazil

[3] Univ Fed Pernambuco, Dept Neuropsiquiatria, Recife, PE, Brazil

[4] Univ Fed Pernambuco, Dept Zool, Recife, PE, Brazil

来源：

PRION | 2017年 / 11卷 / 01期

关键词：

Blastocerus; chronic wasting disease; Mazama; neotropical deer; Ozotocerus; PrP; prion; CHRONIC WASTING DISEASE; WHITE-TAILED DEER; CERVUS-ELAPHUS-NELSONI; SUSCEPTIBILITY; GENE; ELK; POLYMORPHISMS;

D O I：

10.1080/19336896.2016.1274000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prion diseases are neurodegenerative fatal disorders that affect human and non-human mammals. Chronic Wasting Disease (CWD) is a prion disease of cervids regarded as a public health problem in North America, and polymorphisms at specific codons in the PRNP gene are associated with this disease. To assess the potential CWD susceptibility of South American free-ranging deer, the presence of these polymorphisms was examined in Mazama gouazoubira, Ozotoceros bezoarticus and Blastocerus dichotomus. Despite the lack of CWD reports in Brazil, the examined codons (95, 96, 116, 132, 225, and 226) of the PRNP gene showed potential CWD susceptibility in Brazilian deer. Low abundancy of deer in Brazil possibly difficult both CWD proliferation and detection, however, CWD surveillance may not be neglected.

引用

页码：65 / 70

页数：6

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