Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor

被引：25
|
作者：
Huang, Qiaoxian [1 ]
Kuok, Kit Ieng [1 ]
Zhang, Xiangjun [1 ,2 ]
Yue, Ludan [1 ]
Lee, Simon M. Y. [1 ]
Zhang, Jianxiang [2 ]
Wang, Ruibing [1 ]
机构：
[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China
[2] Third Mil Med Univ, Coll Pharm, Dept Pharmaceut, Chongqing 400038, Peoples R China
来源：
NANOSCALE | 2018年 / 10卷 / 22期
关键词：
NEUROMUSCULAR BLOCK; GENERAL-ANESTHESIA; IN-VIVO; CHEMISTRY; EPILEPSY; HOST;
D O I：
10.1039/c8nr02041h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A synthetic nanoreceptor, cucurbit[7]uril (CB[7]), fully encapsulated pentylenetetrazol (PTZ), a seizure-inducing model drug. As a consequence of the encapsulation, the development of PTZ induced convulsion behaviors in both larval zebrafish and mouse models were dramatically alleviated, suggesting that CB[7] holds great neuroprotection potential against neurotoxic drugs for clinical applications.
引用
收藏
页码：10333 / 10336
页数：5
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