Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor

被引：25

作者：

Huang, Qiaoxian ^{[1
]}

Kuok, Kit Ieng ^{[1
]}

Zhang, Xiangjun ^{[1
,2
]}

Yue, Ludan ^{[1
]}

Lee, Simon M. Y. ^{[1
]}

Zhang, Jianxiang ^{[2
]}

Wang, Ruibing ^{[1
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China

[2] Third Mil Med Univ, Coll Pharm, Dept Pharmaceut, Chongqing 400038, Peoples R China

来源：

NANOSCALE | 2018年 / 10卷 / 22期

关键词：

NEUROMUSCULAR BLOCK; GENERAL-ANESTHESIA; IN-VIVO; CHEMISTRY; EPILEPSY; HOST;

D O I：

10.1039/c8nr02041h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synthetic nanoreceptor, cucurbit[7]uril (CB[7]), fully encapsulated pentylenetetrazol (PTZ), a seizure-inducing model drug. As a consequence of the encapsulation, the development of PTZ induced convulsion behaviors in both larval zebrafish and mouse models were dramatically alleviated, suggesting that CB[7] holds great neuroprotection potential against neurotoxic drugs for clinical applications.

引用

页码：10333 / 10336

页数：5

共 35 条

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