Histological analysis of socket preservation using DBBM. A systematic review and meta-analysis

Purpose: Deproteinized bovine bone mineral (DBBM) is a type of bone substitute material widely used in tooth extraction sites. However, there is a lack of evidence supporting the benefit of DBBM used for postextraction socket preservation with regard to new bone formation. This meta-analysis and systematic review was conducted to explore whether site preservation (SP) using DBBM could provide benefits with regard to new bone formation compared with natural healing. Materials and methods: Studies reporting histological results for postextraction SP with DBBM and natural healing from 2000 to 2019 were identified in three databases, and a meta-analysis was conducted. Results: Five studies were included. The DBBM group had a significantly lower new bone percentage than the natural healing group, with a MD of-24.75 [95% CI:-39.77,-9.73] (P = 0.001). The percentage of connective tissue in the extraction site was not significantly different between the two groups, with a MD of 0.60 [95% CI:-4.85, 6.05] (P = 0.83). Conclusions: SP using DBBM provided no additional benefit with regard to postextraction new bone formation in comparison with natural healing. Due to the lack of high-quality research, further large sample studies and standard studies are needed to confirm these conclusions. (C)2020 Published by Elsevier Masson SAS.