Biomimetic drug nanocarriers prepared by miniemulsion polymerization for near-infrared imaging and photothermal therapy

被引：24

作者：

Han, Haijie ^{[1
]}

Zhang, Shimiao ^{[1
]}

Wang, Yin ^{[1
]}

Chen, Tingting ^{[1
]}

Jin, Qiao ^{[1
]}

Chen, Yangjun ^{[1
]}

Li, Zuhong ^{[1
]}

Ji, Jian ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, Minist Educ, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China

来源：

POLYMER | 2016年 / 82卷

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

Miniemulsion polymerization; Phosphorylcholine; IR-780; Near-infrared imaging; Photothermal therapy; INDOCYANINE-GREEN; THERANOSTIC NANOPARTICLES; DELIVERY; PHOSPHORYLCHOLINE; CHEMOTHERAPY; DENDRIMER; MECHANISM; MICELLES; PLATFORM; RELEASE;

D O I：

10.1016/j.polymer.2015.11.022

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Miniemulsion reversible addition-fragmentation chain transfer (RAFT) polymerization was used to synthesize biomimetic poly (2-methacryloyloxyethyl phosphorylcholine)-b-Poly (n-butyl methacrylate) (PMPC-b-PBMA) nanoparticles which were used as nanocarriers to encapsulate theranostic IR-780 molecules. IR-780 endowed the PMPC-b-PBMA nanoparticles with dual functions including tumor near-infrared (NIR) imaging and photothermal therapy (PTT). The IR-780 encapsulated PMPC-b-PBMA (PMPC-b-PBMA/IR-780) nanoparticles showed good monodispersity and significant stability. The photothermal effects and photothermal cytotoxicity of the PMPC-b-PBMA/IR-780 nanoparticles were studied in vitro. High accumulation of the PMPC-b-PBMA/IR-780 nanoparticles in tumor tissue was verified by whole-animal NIR imaging. The resulted IR-780 encapsulated biomimetic nanoparticles can be an alternative safe theranostic agent for imaging-guided cancer treatment. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：255 / 261

页数：7

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