Biomimetic drug nanocarriers prepared by miniemulsion polymerization for near-infrared imaging and photothermal therapy

被引：24

作者：

Han, Haijie ^{[1
]}

Zhang, Shimiao ^{[1
]}

Wang, Yin ^{[1
]}

Chen, Tingting ^{[1
]}

Jin, Qiao ^{[1
]}

Chen, Yangjun ^{[1
]}

Li, Zuhong ^{[1
]}

Ji, Jian ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, Minist Educ, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China

来源：

POLYMER | 2016年 / 82卷

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

Miniemulsion polymerization; Phosphorylcholine; IR-780; Near-infrared imaging; Photothermal therapy; INDOCYANINE-GREEN; THERANOSTIC NANOPARTICLES; DELIVERY; PHOSPHORYLCHOLINE; CHEMOTHERAPY; DENDRIMER; MECHANISM; MICELLES; PLATFORM; RELEASE;

D O I：

10.1016/j.polymer.2015.11.022

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Miniemulsion reversible addition-fragmentation chain transfer (RAFT) polymerization was used to synthesize biomimetic poly (2-methacryloyloxyethyl phosphorylcholine)-b-Poly (n-butyl methacrylate) (PMPC-b-PBMA) nanoparticles which were used as nanocarriers to encapsulate theranostic IR-780 molecules. IR-780 endowed the PMPC-b-PBMA nanoparticles with dual functions including tumor near-infrared (NIR) imaging and photothermal therapy (PTT). The IR-780 encapsulated PMPC-b-PBMA (PMPC-b-PBMA/IR-780) nanoparticles showed good monodispersity and significant stability. The photothermal effects and photothermal cytotoxicity of the PMPC-b-PBMA/IR-780 nanoparticles were studied in vitro. High accumulation of the PMPC-b-PBMA/IR-780 nanoparticles in tumor tissue was verified by whole-animal NIR imaging. The resulted IR-780 encapsulated biomimetic nanoparticles can be an alternative safe theranostic agent for imaging-guided cancer treatment. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：255 / 261

页数：7

共 41 条

[1] Supramolecular Nanodevices: From Design Validation to Theranostic Nanomedicine [J].

Cabral, Horacio ;

Nishiyama, Nobuhiro ;

Kataoka, Kazunori .

ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :999-1008

[2] PSMA-Targeted Theranostic Nanoplex for Prostate Cancer Therapy [J].

Chen, Zhihang ;

Penet, Marie-France ;

Nimmagadda, Sridhar ;

Li, Cong ;

Banerjee, Sangeeta R. ;

Winnard, Paul T., Jr. ;

Artemov, Dmitri ;

Glunde, Kristine ;

Pomper, Martin G. ;

Bhujwalla, Zaver M. .

ACS NANO, 2012, 6 (09) :7752-7762

[3] Hepatocyte-targeted fluorescent nanoparticles based on a polyaspartamide for potential theranostic applications [J].

Craparo, Emanuela Fabiola ;

Licciardi, Mariano ;

Conigliaro, Alice ;

Palumbo, Fabio Salvatore ;

Giammona, Gaetano ;

Alessandro, Riccardo ;

De Leo, Giacomo ;

Cavallaro, Gennara .

POLYMER, 2015, 70 :257-270

[4]

Dzurinko Victoria L, 2004, Optometry, V75, P743, DOI 10.1016/S1529-1839(04)70234-1

[5] Molecularly imprinted nanoparticles prepared by miniemulsion polymerization as selective receptors and new carriers for the sustained release of carbamazepine [J].

Esfandyari-Manesh, Mehdi ;

Javanbakht, Mehran ;

Dinarvand, Rassoul ;

Atyabi, Fatemeh .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2012, 23 (04) :963-972

[6]

Fang J, 2003, ADV EXP MED BIOL, V519, P29

[7] Cobalt and nickel nanoparticles fabricated p(NIPAM-co-MAA) microgels for catalytic applications [J].

Farooqi, Zahoor H. ;

Iqbal, Sadia ;

Khan, Shanza Rauf ;

Kanwal, Farah ;

Begum, Robina .

E-POLYMERS, 2014, 14 (05) :313-321

[8] Polyether based amphiphiles for delivery of active components [J].

Gupta, Shilpi ;

Tyagi, Rahul ;

Parmar, Virinder S. ;

Sharma, Sunil K. ;

Haag, Rainer .

POLYMER, 2012, 53 (15) :3053-3078

[9] Cell-specific delivery of polymeric nanoparticles to carbohydrate-tagging cells [J].

Iwasaki, Yasuhiko ;

Maie, Haruki ;

Akiyoshi, Kazunari .

BIOMACROMOLECULES, 2007, 8 (10) :3162-3168

[10] Zwitterionic phosphorylcholine as a better ligand for stabilizing large biocompatible gold nanoparticles [J].

Jin, Qiao ;

Xu, Jian-Ping ;

Ji, Jian ;

Shen, Jia-Cong .

CHEMICAL COMMUNICATIONS, 2008, (26) :3058-3060

← 1 2 3 4 5 →