Catalyst-free three-component synthesis of highly functionalized 2,3-dihydropyrroles

被引：8

作者：

Wang, Dong ^{[1
]}

Li, Linna ^{[1
]}

Feng, Hairong ^{[1
]}

Sun, Hua ^{[1
]}

Almeida-Veloso, Fabrice ^{[2
]}

Charavin, Marine ^{[2
]}

Yu, Peng ^{[1
]}

Desaubry, Laurent ^{[1
,2
,3
]}

机构：

[1] Tianjin Univ Sci & Technol, Sino French Joint Lab Food Nutr Safety & Med Chem, China Int Sci & Technol Cooperat Base Food Nutr S, Coll Biotechnol, Tianjin 300457, Peoples R China

[2] Univ Strasbourg, Lab Therapeut Innovat UMR 7200, Fac Pharm, CNRS, F-67400 Illkirch Graffenstaden, France

[3] Sorbonne Univ, Lab Biomol UMR7203, CNRS, 4 Pl Jussieu, F-75005 Paris, France

来源：

GREEN CHEMISTRY | 2018年 / 20卷 / 12期

基金：

中国国家自然科学基金;

关键词：

TETRACYCLIC OXINDOLE DERIVATIVES; ALPHA-GLUCOSIDASE INHIBITORS; MULTICOMPONENT REACTIONS; DRUG DISCOVERY; ENANTIOSELECTIVE SYNTHESIS; EMERGING CHEMISTRY; AZOMETHINE YLIDES; CONSTRUCTION; SCAFFOLD; TETRAHYDROQUINOLINES;

D O I：

10.1039/c8gc00987b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of fully substituted 2,3-dihydropyrroles has been achieved in one step through the three-component reaction of amines, aromatic aldehydes and a-ketoamides. This atom-economical and catalyst-free reaction is highly stereoselective and generates underexplored heterocycles in a single step. These compounds were examined in an enzymatic assay that led to the identification of potent a-glucosidase inhibitors, thereby demonstrating the utility of this novel methodology in medicinal chemistry.

引用

页码：2775 / 2780

页数：6

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