Testicular Germ-Cell Tumours: A Descriptive Analysis of Clinical Characteristics at First Presentation

被引：55

作者：

Dieckmann, Klaus-Peter ^{[1
,2
]}

Richter-Simonsen, Hanna ^{[1
]}

Kulejewski, Magdalena ^{[1
]}

Ikogho, Raphael ^{[1
]}

Zecha, Henrik ^{[1
]}

Anheuser, Petra ^{[1
]}

Pichlmeier, Uwe ^{[3
]}

Isbarn, Hendrik ^{[4
]}

机构：

[1] Albertinen Krankenhaus Hamburg, Klin Urol, Hamburg, Germany

[2] Hodentumorzentrum Hamburg, Asklepios Klin Altona, Hamburg, Germany

[3] Univ Klinikum Hamburg Eppendorf, Zentrum Expt Med, Inst Med Biometrie, Hamburg, Germany

[4] Univ Klinikum Hamburg Eppendorf, Martini Klin, Hamburg, Germany

来源：

UROLOGIA INTERNATIONALIS | 2018年 / 100卷 / 04期

关键词：

Germ cell tumour; Seminoma; Nonseminoma; Clinical staging; Tumour markers; Tumour size; CANCER REGISTRATION COMMITTEE; HUMAN CHORIONIC-GONADOTROPIN; PREDICTIVE FACTORS; TESTIS CANCER; LARGE-SCALE; STAGE; EXPERIENCE; SURVIVAL; CLASSIFICATION; MANAGEMENT;

D O I：

10.1159/000488284

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Clinical characteristics of testicular germ cell tumours (GCTs) apparently change over time, and some vary geographically. The aim of this study is to document the clinical profile of contemporary GCT patients. Patients and Methods: Four hundred twenty-two Caucasian GCT-patients treated in one German centre during 2000-2017, were analysed in terms of patient-age, laterality, histology, tumoursize, clinical stages (CS), pathological (pT)-stages and serum biomarker expression. The results were analysed descriptively and compared with the literature. Results: Median age was 36 years and 60.2% had seminoma.Beta-human chorionic gonadotropin was expressed in 37.9% and alpha Fetoprotein in 25.6%. CS1 presenting stage was 66.6% of all GCT patients, 79.1% in seminoma, and 47.6% in nonseminoma. Tumour size was significantly associated with pT-stages and CS. Patients >50 years had significantly more seminoma (77.6%) than younger ones (57.9%). Comparison with literature data revealed a shifting towards higher age, lower CS, higher proportion of seminoma and striking differences of characteristics among geographic regions. Conclusions: A typical contemporary clinical profile of testicular GCTs is presented in this study. Median age, relative incidence of seminoma and proportion of CS1 appear to be increasing over time. Striking differences among ethnic groups regarding the characteristics of GCT require further investigation. (C) 2018 The Author(s) Published by S. Karger AG, Basel

引用

页码：409 / 419

页数：11

共 65 条

[1] Incorporating age into International Germ Cell Consensus Classification (IGCCC): a time to move forward? [J].

Abdel-Rahman, Omar .

EXPERT REVIEW OF ANTICANCER THERAPY, 2018, 18 (01) :101-105

[2]

Adra N, 2017, CLIN ADV HEMATOL ONC, V15, P386

[3] Testicular germ cell tumours in Iceland -: A nationwide clinicopathological study [J].

Agnarsson, Bjarni A. ;

Gudbjartsson, Tomas ;

Einarsson, Gudmundur Vikar ;

Magnusson, Kjartan ;

Thoroddsen, Asgeir ;

Bergthorsson, Jon Thor ;

Amundadottir, Laufey ;

Barkardottir, Rosa B. ;

Bjornsson, Johannes .

APMIS, 2006, 114 (11) :779-783

[4] Guidelines on Testicular Cancer: 2015 Update [J].

Albers, Peter ;

Albrecht, Walter ;

Algaba, Ferran ;

Bokemeyer, Carsten ;

Cohn-Cedermark, Gabriella ;

Fizazi, Karim ;

Horwich, Alan ;

Laguna, Maria Pilar ;

Nicolai, Nicola ;

Oldenburg, Jan .

EUROPEAN UROLOGY, 2015, 68 (06) :1054-1068

[5]

BACH D, 1977, MUNCHEN MED WOCHEN, V119, P291

[6] Teratoma in the orchiectomy specimen and volume of metastasis are predictors of retroperitoneal teratoma in post-chemotherapy nonseminomatous testis cancer [J].

Beck, SDW ;

Foster, RS ;

Bihrle, R ;

Ulbright, T ;

Koch, MO ;

Wahle, GR ;

Einhorn, LH ;

Donohue, JP .

JOURNAL OF UROLOGY, 2002, 168 (04) :1402-1404

[7] Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer [J].

Beyer, J. ;

Albers, P. ;

Altena, R. ;

Aparicio, J. ;

Bokemeyer, C. ;

Busch, J. ;

Cathomas, R. ;

Cavallin-Stahl, E. ;

Clarke, N. W. ;

Classen, J. ;

Cohn-Cedermark, G. ;

Dahl, A. A. ;

Daugaard, G. ;

De Giorgi, U. ;

De Santis, M. ;

De Wit, M. ;

De Wit, R. ;

Dieckmann, K. P. ;

Fenner, M. ;

Fizazi, K. ;

Flechon, A. ;

Fossa, S. D. ;

Germa Lluch, J. R. ;

Gietema, J. A. ;

Gillessen, S. ;

Giwercman, A. ;

Hartmann, J. T. ;

Heidenreich, A. ;

Hentrich, M. ;

Honecker, F. ;

Horwich, A. ;

Huddart, R. A. ;

Kliesch, S. ;

Kollmannsberger, C. ;

Krege, S. ;

Laguna, M. P. ;

Looijenga, L. H. J. ;

Lorch, A. ;

Lotz, J. P. ;

Mayer, F. ;

Necchi, A. ;

Nicolai, N. ;

Nuver, J. ;

Oechsle, K. ;

Oldenburg, J. ;

Oosterhuis, J. W. ;

Powles, T. ;

Rajpert-De Meyts, E. ;

Rick, O. ;

Rosti, G. .

ANNALS OF ONCOLOGY, 2013, 24 (04) :878-888

[8] Assessing the size and stage of testicular germ cell tumours: 1984-2003 [J].

Bhardwa, JM ;

Powles, T ;

Berney, D ;

Baithun, S ;

Nargund, VH ;

Oliver, RTD .

BJU INTERNATIONAL, 2005, 96 (06) :819-821

[9]

Boormans JL, 2017, EUR UROL

[10]

BOSL GJ, 1988, CANCER RES, V48, P3524

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