Warfarin embryopathy

被引：10

作者：

Bony, C

Zyka, F

Tiran-Rajaofera, I

Attali, T

De Napoli, S

Alessandri, JL ^{[1
]}

机构：

[1] CHD Felix Guyon, Serv Reanimat Neonatale, F-97405 St Denis Messageries, Reunion, France

[2] CHD Felix Guyon, Serv Pediat, F-97405 St Denis Messageries, Reunion, France

[3] CHD Felix Guyon, Serv Chirurg Infantile, F-97405 St Denis Messageries, Reunion, France

来源：

ARCHIVES DE PEDIATRIE | 2002年 / 9卷 / 07期

关键词：

warfarin; fetal diseases; chondrodysplasia punctata; infant; newborn; prenatal exposure delayed effects;

D O I：

10.1016/S0929-693X(01)00970-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report a case of warfarin embryopathy. This disease affects more than 6% of fetuses exposed in utero to a vitamin K antagonist. Observation. - A child whose mother was treated with acenocoumarol because of a mechanical heart valve presented with signs of warfarin embryopathy. He showed chondrodysplasia punctata with telebrachydactyly, facial dysmorphism with nasal hypoplasia, a cataract, and a bilateral pyeloureteral junction syndrome. Comments. - Characteristics of this drug induced embryopathy are reminded, while bearing in mind the conflict of interests between the mother and the fetus. The mechanisms of this embryopathy are debated in light of the recent knowledge concerning fetal metabolism of vitamin K. (C) 2002 Editions scientifiques et medicales Elsevier SAS.

引用

页码：705 / 708

页数：4

共 9 条

[1] Anticoagulation of pregnant women with mechanical heart valves -: A systematic review of the literature [J].