Near-infrared photon time-of-flight spectroscopy of turbid materials up to 1400 nm

被引:44
作者
Svensson, Tomas [1 ]
Alerstam, Erik [1 ]
Khoptyar, Dmitry [1 ]
Johansson, Jonas [2 ]
Folestad, Staffan [2 ]
Andersson-Engels, Stefan [1 ]
机构
[1] Lund Univ, Dept Phys, S-22100 Lund, Sweden
[2] AstraZeneca R&D, S-43183 Molndal, Sweden
关键词
acousto-optical filters; gallium arsenide; gallium compounds; III-V semiconductors; indium compounds; infrared spectroscopy; measurement by laser beam; microchannel plates; photomultipliers; polymers; spectrochemical analysis; time of flight spectroscopy; turbidity; RESOLVED SPECTROSCOPY; CRYSTAL FIBER; MIGRATION; SOLIDS; REFLECTANCE; SCATTER; TISSUE; BRAIN; MODEL;
D O I
10.1063/1.3156047
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
Photon time-of-flight spectroscopy (PTOFS) is a powerful tool for analysis of turbid materials. We have constructed a time-of-flight spectrometer based on a supercontinuum fiber laser, acousto-optical tunable filtering, and an InP/InGaAsP microchannel plate photomultiplier tube. The system is capable of performing PTOFS up to 1400 nm, and thus covers an important region for vibrational spectroscopy of solid samples. The development significantly increases the applicability of PTOFS for analysis of chemical content and physical properties of turbid media. The great value of the proposed approach is illustrated by revealing the distinct absorption features of turbid epoxy resin. Promising future applications of the approach are discussed, including quantitative assessment of pharmaceuticals, powder analysis, and calibration-free near-infrared spectroscopy.
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页数:3
相关论文
共 29 条
[1]   Scatter correction of transmission near-infrared spectra by photon migration data:: Quantitative analysis of solids [J].
Abrahamsson, C ;
Löwgren, A ;
Strömdahl, B ;
Svensson, T ;
Andersson-Engels, S ;
Johansson, J ;
Folestad, S .
APPLIED SPECTROSCOPY, 2005, 59 (11) :1381-1387
[2]   Time and wavelength resolved spectroscopy of turbid media using light continuum generated in a crystal fiber [J].
Abrahamsson, C ;
Svensson, T ;
Svanberg, S ;
Andersson-Engels, S ;
Johansson, J ;
Folestad, S .
OPTICS EXPRESS, 2004, 12 (17) :4103-4112
[3]   Improved accuracy in time-resolved diffuse reflectance spectroscopy [J].
Alerstam, Erik ;
Andersson-Engels, Stefan ;
Svensson, Tomas .
OPTICS EXPRESS, 2008, 16 (14) :10440-10454
[4]   White Monte Carlo for time-resolved photon migration [J].
Alerstam, Erik ;
Andersson-Engels, Stefan ;
Svensson, Tomas .
JOURNAL OF BIOMEDICAL OPTICS, 2008, 13 (04)
[5]   Time-resolved spectrophotometer for turbid media based on supercontinuum generation in a photonic crystal fiber [J].
Bassi, A ;
Swartling, J ;
D'Andrea, C ;
Pifferi, A ;
Torricelli, A ;
Cubeddu, R .
OPTICS LETTERS, 2004, 29 (20) :2405-2407
[6]   Near-infrared spectroscopy in the pharmaceutical industry [J].
Blanco, M ;
Coello, J ;
Iturriaga, H ;
Maspoch, S ;
de la Pezuela, C .
ANALYST, 1998, 123 (08) :135R-150R
[7]   NIR spectroscopy: a rapid-response analytical tool [J].
Blanco, M ;
Villarroya, I .
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2002, 21 (04) :240-250
[8]   COMPARISON OF TIME-RESOLVED AND TIME-UNRESOLVED MEASUREMENTS OF DEOXYHEMOGLOBIN IN BRAIN [J].
CHANCE, B ;
LEIGH, JS ;
MIYAKE, H ;
SMITH, DS ;
NIOKA, S ;
GREENFELD, R ;
FINANDER, M ;
KAUFMANN, K ;
LEVY, W ;
YOUNG, M ;
COHEN, P ;
YOSHIOKA, H ;
BORETSKY, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (14) :4971-4975
[9]   TIME-RESOLVED SPECTROSCOPY OF HEMOGLOBIN AND MYOGLOBIN IN RESTING AND ISCHEMIC MUSCLE [J].
CHANCE, B ;
NIOKA, S ;
KENT, J ;
MCCULLY, K ;
FOUNTAIN, M ;
GREENFELD, R ;
HOLTOM, G .
ANALYTICAL BIOCHEMISTRY, 1988, 174 (02) :698-707
[10]   Phase measurement of light absorption and scatter in human tissue [J].
Chance, B ;
Cope, M ;
Gratton, E ;
Ramanujam, N ;
Tromberg, B .
REVIEW OF SCIENTIFIC INSTRUMENTS, 1998, 69 (10) :3457-3481