Total Synthesis and Structure-Activity Relationship of Glycoglycerolipids from Marine Organisms

被引：39
作者：
Zhang, Jun [1 ]
Li, Chunxia [1 ]
Yu, Guangli [1 ]
Guan, Huashi [1 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China
来源：
MARINE DRUGS | 2014年 / 12卷 / 06期
基金：
中国国家自然科学基金;
关键词：
glycoglycerolipids; marine-origin; bioactivities; total synthesis; structure-activity relationship; O-ALKYL-DIGLYCOSYLGLYCEROLS; FATTY-ACID MONOESTERS; DNA-POLYMERASE-ALPHA; CHEMOENZYMATIC SYNTHESIS; REVERSE-TRANSCRIPTASE; GREEN-ALGA; RED ALGA; ANTIPROLIFERATIVE ACTIVITY; GLYCOSYL DIACYLGLYCEROLS; GLYCOLIPIDS FRACTION;
D O I：
10.3390/md12063634
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Glycoglycerolipids occur widely in natural products, especially in the marine species. Glycoglycerolipids have been shown to possess a variety of bioactivities. This paper will review the different methodologies and strategies for the synthesis of biological glycoglycerolipids and their analogs for bioactivity assay. In addition, the bioactivities and structure-activity relationship of the glycoglycerolipids are also briefly outlined.
引用
收藏
页码：3634 / 3659
页数：26
相关论文
共 110 条
  • [1] Glycolipids from the red alga Chondria armata (Kutz.) Okamura
    Al-Fadhli, Ammar
    Wahidulla, Solimabi
    D'Souza, Lisette
    [J]. GLYCOBIOLOGY, 2006, 16 (10) : 902 - 915
  • [2] SYNTHESIS OF 3-AMINO-3-DEOXY-5-THIO-D-ALLOSE AND 3-AMINO-3-DEOXY-1,2-O - 5,6-S,O-DI-ISOPROPYLIDENE-5-THIO-ALPHA-D-GLUCOFURANOSE
    ALMASOUDI, NAL
    TOOMA, NJ
    [J]. CARBOHYDRATE RESEARCH, 1993, 239 : 273 - 278
  • [3] Continuous measurement of galactolipid hydrolysis by pancreatic lipolytic enzymes using the pH-stat technique and a medium chain monogalactosyl diglyceride as substrate
    Amara, Sawsan
    Lafont, Dominique
    Fiorentino, Brice
    Boullanger, Paul
    Carriere, Frederic
    De Caro, Alain
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2009, 1791 (10): : 983 - 990
  • [4] Avrainvilloside, a 6-deoxy-6-aminoglucoglycerolipid from the green alga Avrainvillea nigricans
    Andersen, RJ
    Taglialatela-Scafati, O
    [J]. JOURNAL OF NATURAL PRODUCTS, 2005, 68 (09): : 1428 - 1430
  • [5] Mammalian mitotic centromere-associated kinesin (MCAK) - A new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents
    Aoki, S
    Ohta, K
    Yamazaki, T
    Sugawara, F
    Sakaguchi, K
    [J]. FEBS JOURNAL, 2005, 272 (09) : 2132 - 2140
  • [6] Myrmekiosides A and B, novel mono-O-alkyl-diglycosylglycerols reversing tumor cell morphology of ras-transformed cells from a marine sponge of Myrmekioderma sp.
    Aoki, S
    Higuchi, K
    Kato, A
    Murakami, N
    Kobayashi, M
    [J]. TETRAHEDRON, 1999, 55 (52) : 14865 - 14870
  • [7] A novel glycolipid 1,2-diacyl-3-alpha-D-glucuronopyranosyl-sn-glycerol taurineamide, from the budding seawater bacterium Hyphomonas jannaschiana
    Batrakov, SG
    Nikitin, DI
    Pitryuk, IA
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1996, 1302 (02): : 167 - 176
  • [8] Biosynthesis and function of the sulfolipid sulfoquinovosyl diacylglycerol
    Benning, C
    [J]. ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY, 1998, 49 : 53 - 75
  • [9] A SULFOLIPID IN PLANTS
    BENSON, AA
    DANIEL, H
    WISER, R
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1959, 45 (11) : 1582 - 1587
  • [10] In vitro anti-inflammatory and anti-proliferative activity of sulfolipids from the red alga Porphyridium cruentum
    Bergé, JP
    Debiton, E
    Dumay, J
    Durand, P
    Barthomeuf, C
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (21) : 6227 - 6232
12345678910