Understanding the Colloidal Stability of the Mesoporous MIL-100(Fe) Nanoparticles in Physiological Media

被引：128
作者：
Bellido, Elena [1 ]
Guillevic, Mazheva [1 ]
Hidalgo, Tania [1 ]
Santander-Ortega, Manuel J. [2 ]
Serre, Christian [1 ]
Horcajada, Patricia [1 ]
机构：
[1] Univ Versailles St Quentin En Yvelines, UMR CNRS 8180, Inst Lavoisier Versailles, F-78035 Versailles, France
[2] Univ Santiago de Compostela, Nanobiofar Ctr Mol Med & Chron Dis CIMUS, Santiago De Compostela 15706, Spain
来源：
LANGMUIR | 2014年 / 30卷 / 20期
关键词：
METAL-ORGANIC FRAMEWORKS; BOVINE SERUM-ALBUMIN; DRUG-DELIVERY; PARTICLES; MOLECULES; POLOXAMER; SYSTEMS; PLGA;
D O I：
10.1021/la5012555
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The colloidal and chemical stability of nanoparticles of the nontoxic and biodegradable iron(III) trimesate MIL-100(Fe) nanocarrier have been evaluated in the presence of a series of simulated physiological fluids for intravenous and oral administration. MIL-100(Fe) nanoparticles exhibit an appropriate colloidal stability and biodegradability, mainly dependent on both the nature of their physicochemical surface and the media composition, being a priori compatible with their biomedical use.
引用
收藏
页码：5911 / 5920
页数：10
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