Understanding the Colloidal Stability of the Mesoporous MIL-100(Fe) Nanoparticles in Physiological Media

被引：130

作者：

Bellido, Elena ^{[1
]}

Guillevic, Mazheva ^{[1
]}

Hidalgo, Tania ^{[1
]}

Santander-Ortega, Manuel J. ^{[2
]}

Serre, Christian ^{[1
]}

Horcajada, Patricia ^{[1
]}

机构：

[1] Univ Versailles St Quentin En Yvelines, UMR CNRS 8180, Inst Lavoisier Versailles, F-78035 Versailles, France

[2] Univ Santiago de Compostela, Nanobiofar Ctr Mol Med & Chron Dis CIMUS, Santiago De Compostela 15706, Spain

来源：

LANGMUIR | 2014年 / 30卷 / 20期

关键词：

METAL-ORGANIC FRAMEWORKS; BOVINE SERUM-ALBUMIN; DRUG-DELIVERY; PARTICLES; MOLECULES; POLOXAMER; SYSTEMS; PLGA;

D O I：

10.1021/la5012555

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The colloidal and chemical stability of nanoparticles of the nontoxic and biodegradable iron(III) trimesate MIL-100(Fe) nanocarrier have been evaluated in the presence of a series of simulated physiological fluids for intravenous and oral administration. MIL-100(Fe) nanoparticles exhibit an appropriate colloidal stability and biodegradability, mainly dependent on both the nature of their physicochemical surface and the media composition, being a priori compatible with their biomedical use.

引用

页码：5911 / 5920

页数：10

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