Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input

被引：42

作者：

Weng, Yue ^{[1
,2
]}

Song, Chunlan ^{[3
]}

Chiang, Chien-Wei ^{[3
]}

Lei, Aiwen ^{[3
]}

机构：

[1] Hubei Univ, Key Lab Synth & Applicat Organ Funct Mol, Minist Of Educ, Wuhan 430062, Hubei, Peoples R China

[2] Hubei Univ, Sch Chem & Chem Engn, Wuhan 430062, Hubei, Peoples R China

[3] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China

来源：

COMMUNICATIONS CHEMISTRY | 2020年 / 3卷 / 01期

基金：

中国国家自然科学基金;

关键词：

PEPTIDE; SITE; ARYLATION; PROTEINS; CHEMISTRY; TYROSINE; BATCH; TRIFLUOROMETHYLATION; FUNCTIONALIZATION; MACROCYCLIZATION;

D O I：

10.1038/s42004-020-00413-x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bioconjugation reactions play a central facilitating role in engendering modified peptides and proteins. Early progress in this area was inhibited by challenges such as the limited range of substrates and the relatively poor biocompatibility of bioconjugation reagents. However, the recent developments in visible-light induced photoredox catalysis and electrochemical catalysis reactions have permitted significant novel reactivities to be developed in the field of synthetic and bioconjugation chemistry. This perspective describes recent advances in the use of biocompatible energy input for the modification of peptides and proteins mainly, via the single electron transfer (SET) process, as well as key future developments in this area.

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