New strategy to control cell migration and metastasis regulated by CCN2/CTGF

被引：41

作者：

Aguiar, Diego Pinheiro ^{[1
]}

de Farias, Gabriel Correa ^{[1
]}

de Sousa, Eduardo Branco ^{[1
]}

Coelho-Aguiar, Juliana de Mattos ^{[2
]}

Lobo, Julie Calixto ^{[1
]}

Casado, Priscila Ladeira ^{[1
]}

Leite Duarte, Maria Eugenia ^{[1
]}

Ribeiro Abreu, Jose Garcia, Jr. ^{[2
]}

机构：

[1] Natl Inst Traumatol & Orthoped, Div Res, Rio De Janeiro, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Inst Biomed Sci, Program Cell & Dev Biol, Rio De Janeiro, RJ, Brazil

来源：

CANCER CELL INTERNATIONAL | 2014年 / 14卷

关键词：

CCN2; CTGF; Adhesion; Migration and Metastasis; TISSUE GROWTH-FACTOR; IMMEDIATE-EARLY GENE; BINDING-PROTEIN SUPERFAMILY; VASCULAR ENDOTHELIAL-CELLS; HEPATIC STELLATE CELLS; HUMAN SKIN FIBROBLASTS; BREAST-CANCER CELLS; FACTOR CTGF; FACTOR CCN2; INTEGRIN ALPHA(V)BETA(3);

D O I：

10.1186/1475-2867-14-61

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth muscle and also pluripotent stem cells. Others matricellular proteins are capable of interacting with CCN2/CTGF to mediate its function. Cell migration is a key feature for tumor cell invasion and metastasis. CCN2/CTGF seems to be a prognostic marker for cancer. In addition, here we intend to discuss recent discoveries and a new strategy to develop therapies against CCN2/CTGF, in order to treat cancer metastasis.

引用

页数：7

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