Androgens and androgen receptor action in skin and hair follicles

被引：124

作者：

Maria Ceruti, Julieta ^{[1
]}

Jose Leiros, Gustavo ^{[1
]}

Eugenia Balana, Maria ^{[1
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn, Inst Ciencia & Tecnol Dr Cesar Milstein, C1440FFX, RA-2468 Buenos Aires, Argentina

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2018年 / 465卷 / 0C期

关键词：

Skin steroidogenesis in health and disease; Androgenetic alopecia; Epithelial-mesenchymal interactions; Dermal papilla; Wnt/beta-catenin signaling; DERMAL PAPILLA CELLS; STEROID-HORMONE RECEPTORS; MESSENGER-RNA EXPRESSION; APOCRINE SWEAT GLANDS; PROSTATE-CANCER; PROPIONIBACTERIUM-ACNES; IN-VITRO; 5-ALPHA-REDUCTASE ACTIVITY; HIDRADENITIS SUPPURATIVA; MOLECULAR MECHANISMS;

D O I：

10.1016/j.mce.2017.09.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Beyond sexual functions, androgens exert their action in skin physiology and pathophysiology. Skin cells are able to synthesize most active androgens from gonadal or adrenal precursors and the enzymes involved in skin steroidogenesis are implicated both in normal or pathological processes. Even when the role of androgens and androgen receptor (AR) in skin pathologies has been studied for decades, their molecular mechanisms in skin disorders remain largely unknown. Here, we analyze recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of their molecular mechanisms in androgenetic alopecia (AGA). We review the molecular pathophysiology of type 25 alpha-reductase, AR coactivators, the paracrine factors deregulated in dermal papillae (such as TGF-beta, IGF 1, WNTs and DKK-1) and the crosstalk between AR and Wnt signaling in order to shed some light on new promising treatments. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：122 / 133

页数：12

共 170 条

[1] SEBUM LEVELS DURING THE 1ST YEAR OF LIFE [J].