Evolving Marine Biomimetics for Regenerative Dentistry

被引:25
作者
Green, David W. [1 ]
Lai, Wing-Fu [2 ]
Jung, Han-Sung [1 ,2 ]
机构
[1] Univ Hong Kong, Fac Dent, Hong Kong, Peoples R China
[2] Yonsei Univ Coll Dent, Div Anat & Dev Biol, Dept Oral Biol, Oral Sci Res Ctr,PLUS Project BK21, Seoul 120752, South Korea
关键词
regenerative dentistry; biomimetics; marine invertebrates; bone; dentine; REPLAMINEFORM POROUS BIOMATERIALS; MESOPOROUS SILICA NANOPARTICLES; MESENCHYMAL STEM-CELLS; WATER-SOLUBLE MATRIX; OF-THE-ART; IN-VITRO; ALGINATE HYDROGELS; BONE REGENERATION; HUMAN OSTEOBLASTS; NATURAL-PRODUCTS;
D O I
10.3390/md12052877
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
New products that help make human tissue and organ regeneration more effective are in high demand and include materials, structures and substrates that drive cell-to-tissue transformations, orchestrate anatomical assembly and tissue integration with biology. Marine organisms are exemplary bioresources that have extensive possibilities in supporting and facilitating development of human tissue substitutes. Such organisms represent a deep and diverse reserve of materials, substrates and structures that can facilitate tissue reconstruction within lab-based cultures. The reason is that they possess sophisticated structures, architectures and biomaterial designs that are still difficult to replicate using synthetic processes, so far. These products offer tantalizing pre-made options that are versatile, adaptable and have many functions for current tissue engineers seeking fresh solutions to the deficiencies in existing dental biomaterials, which lack the intrinsic elements of biofunctioning, structural and mechanical design to regenerate anatomically correct dental tissues both in the culture dish and in vivo.
引用
收藏
页码:2877 / 2912
页数:36
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