Pre-Freeze and Post-Thaw Characteristics on Chimerism Patterns in Double-unit Cord Blood Transplantation

被引：4
作者：
Jaing, Tang-Her [1 ]
Tsay, Pei-Kwei [2 ,3 ]
Lin, Tung-Liang [4 ]
Yang, Chao-Ping [1 ]
Hung, Iou-Jih [1 ]
Wen, Yu-Chuan [5 ]
机构：
[1] Chang Gung Univ, Chang Gung Mem Hosp, Dept Pediat, Div Hematol & Oncol, Tao Yuan, Taiwan
[2] Chang Gung Univ, Coll Med, Dept Publ Hlth, Tao Yuan, Taiwan
[3] Chang Gung Univ, Coll Med, Ctr Biostat, Tao Yuan, Taiwan
[4] Chang Gung Univ, Chang Gung Mem Hosp, Dept Internal Med, Tao Yuan, Taiwan
[5] Chang Gung Univ, Chang Gung Mem Hosp, Dept Nursing, Tao Yuan, Taiwan
来源：
PEDIATRIC BLOOD & CANCER | 2009年 / 52卷 / 04期
关键词：
cell dose; double cord blood transplantation; neutrophil engraftment; predominant unit; ENGRAFTMENT; ADULTS; LEUKEMIA; OUTCOMES; CELLS;
D O I：
10.1002/pbc.21882
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We analyzed the pre-freeze and post-thaw characteristics on chimerism patterns in 20 cases Of double-unit cord blood transplantation. The cord blood units (CBUs) were a 4/6 HLA match or better with recipients and achieved a minimum combined precryopreservation cell close of 3.7 x 10(7) total nucleated cell (TNC)/kg. The unit with a higher cell dose was infused first. All evaluable patients engrafted at a median of 18 clays. By clay 42, neutrophil engraftment was derived from both donors in 63% of cases and a single donor in 37% of patients. By clay 100, one unit predominated in 80% of the patients. Higher pre-freeze TNC and CD34+ cell closes were associated with cord predominance in 67% of patients. Pediatr Blood Cancer 2009;52:547-550. (C) 2008 Wiley-Liss, Inc.
引用
收藏
页码：547 / 550
页数：4
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