Pre-Freeze and Post-Thaw Characteristics on Chimerism Patterns in Double-unit Cord Blood Transplantation

被引：4

作者：

Jaing, Tang-Her ^{[1
]}

Tsay, Pei-Kwei ^{[2
,3
]}

Lin, Tung-Liang ^{[4
]}

Yang, Chao-Ping ^{[1
]}

Hung, Iou-Jih ^{[1
]}

Wen, Yu-Chuan ^{[5
]}

机构：

[1] Chang Gung Univ, Chang Gung Mem Hosp, Dept Pediat, Div Hematol & Oncol, Tao Yuan, Taiwan

[2] Chang Gung Univ, Coll Med, Dept Publ Hlth, Tao Yuan, Taiwan

[3] Chang Gung Univ, Coll Med, Ctr Biostat, Tao Yuan, Taiwan

[4] Chang Gung Univ, Chang Gung Mem Hosp, Dept Internal Med, Tao Yuan, Taiwan

[5] Chang Gung Univ, Chang Gung Mem Hosp, Dept Nursing, Tao Yuan, Taiwan

来源：

PEDIATRIC BLOOD & CANCER | 2009年 / 52卷 / 04期

关键词：

cell dose; double cord blood transplantation; neutrophil engraftment; predominant unit; ENGRAFTMENT; ADULTS; LEUKEMIA; OUTCOMES; CELLS;

D O I：

10.1002/pbc.21882

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We analyzed the pre-freeze and post-thaw characteristics on chimerism patterns in 20 cases Of double-unit cord blood transplantation. The cord blood units (CBUs) were a 4/6 HLA match or better with recipients and achieved a minimum combined precryopreservation cell close of 3.7 x 10(7) total nucleated cell (TNC)/kg. The unit with a higher cell dose was infused first. All evaluable patients engrafted at a median of 18 clays. By clay 42, neutrophil engraftment was derived from both donors in 63% of cases and a single donor in 37% of patients. By clay 100, one unit predominated in 80% of the patients. Higher pre-freeze TNC and CD34+ cell closes were associated with cord predominance in 67% of patients. Pediatr Blood Cancer 2009;52:547-550. (C) 2008 Wiley-Liss, Inc.

引用

页码：547 / 550

页数：4

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