CNS demyelination and quadrivalent HPV vaccination

被引：83

作者：

Sutton, I. ^{[1
,2
]}

Lahoria, R. ^{[3
]}

Tan, I. L. ^{[2
]}

Clouston, P. ^{[4
]}

Barnett, M. H. ^{[1
,3
]}

机构：

[1] Univ Sydney, Brain & Mind Res Inst, Camperdown, NSW 2050, Australia

[2] St Vincents Hosp, Dept Neurol, Darlinghurst, NSW 2010, Australia

[3] St George Hosp, Kogarah, NSW, Australia

[4] Westmead Hosp, Westmead, NSW 2145, Australia

来源：

MULTIPLE SCLEROSIS JOURNAL | 2009年 / 15卷 / 01期

关键词：

demyelination; multiple sclerosis; human papillomavirus; vaccination; HEPATITIS-B VACCINATION; MULTIPLE-SCLEROSIS; EVENTS;

D O I：

10.1177/1352458508096868

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Vaccination is generally considered safe in patients with multiple sclerosis (MS). We report five patients who presented with multifocal or atypical demyelinating syndromes within 21 days of immunization with the quadrivalent human papilloma virus (HPV) vaccine, Gardasil (R). Although the target population for vaccination, young females, has an inherently high risk for MS, the temporal association with demyelinating events in these cases may be explained by the potent immuno-stimulatory properties of HPV virus-like particles which comprise the vaccine. A prospective case-control study of patients with MS or clinically isolated demyelinating syndromes receiving the Gardasil (R) vaccine may provide relevant safety data in this population. Multiple Sclerosis 2009; 15: 116-119. http://msj.sagepub.com

引用

页码：116 / 119

页数：4

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