Synthesis and Antifungal Activity of 1,2,3-thiadiazole Derivatives Containing 1,3,4-thiadiazole Moiety

被引：86

作者：

Yan, Shui-Lin ^{[1
]}

Yang, Ming-Yan ^{[1
]}

Sun, Zhao-Hui ^{[1
]}

Min, Li-Jing ^{[2
]}

Tan, Cheng-Xia ^{[1
]}

Weng, Jian-Quan ^{[1
]}

Wu, Hong-Ke ^{[1
]}

Liu, Xing-Hai ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

[2] Huzhou Teachers Coll, Coll Life Sci, Huzhou 313000, Zhejiang, Peoples R China

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2014年 / 11卷 / 07期

基金：

中国国家自然科学基金;

关键词：

1,2,3-thiadiazole; 1,3,4-thiadiazole; Antifungal activity; Synthesis; CRYSTAL-STRUCTURE; BIOLOGICAL-ACTIVITY; 1,2,4-TRIAZOLE DERIVATIVES; COMPOUND;

D O I：

10.2174/1570180811666140423222141

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-methyl-N-(5-substituted-1, 3,4-thiadiazol-2-yl)-1,2,3-thiadiazole-5-carboxamide 6a similar to 6j. The chemical structures were confirmed by H-1 NMR, FTIR, MS, and elemental analysis. All the compounds were investigated for antifungal activity. The antifungal activity results indicated that compound 6a exhibited good activities against C. arachidicola. It can be compared with the commercial drug. The compounds 6e, 6f, 6i, 6j exhibited moderate activity.

引用

页码：940 / 943

页数：4

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