Novel sensitive electrochemical sensor for simultaneous determination of epinephrine and uric acid by using a nanocomposite of MWCNTs-chitosan and gold nanoparticles attached to thioglycolic acid

被引：60
作者：
Dorraji, Parisa S. [1 ]
Jalali, Fahimeh [1 ]
机构：
[1] Razi Univ, Fac Sci, Dept Chem, Kermanshah 67346, Kermanshah, Iran
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2014年 / 200卷
关键词：
Simultaneous determination; Epinephrine; Uric acid; Au nanoparticles; Blood serum; DPV; GLASSY-CARBON ELECTRODE; INJECTION CHEMILUMINESCENCE DETERMINATION; PERFORMANCE LIQUID-CHROMATOGRAPHY; NANOTUBE PASTE ELECTRODE; ASCORBIC-ACID; IONIC LIQUID; PHARMACEUTICAL PREPARATIONS; SELECTIVE DETERMINATION; FOLIC-ACID; DOPAMINE;
D O I：
10.1016/j.snb.2014.04.036
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A promising electrochemical sensor for simultaneous determination of epinephrine (EP) and uric acid (UA) was fabricated by electrodeposition of Au-nanoparicles (AuNPs) on thioglycolic acid (TGA) film. TGA film was stabilized by covalent attachment to chitosan-MWCNTs composite on a glassy carbon electrode. The average size of AuNPs obtained by SEM was 110 +/- 5 nm. AuNPs/TGA/CS-MWCNTs/GCE exhibited remarkable electrocatalytic activity towards the oxidation of epinephrine (EP) and uric acid (UA) in the presence of a large excess of ascorbic acid. Under the optimum experimental conditions, the detection limits of 60 nM for EP and 32 nM for UA were achieved by using amperometric method. The sensitivity of the method was 2.31 mu A mu M-1 and 0.45 mu A mu M-1 for EP and UA, respectively. The modified electrode was applied successfully to the simultaneous determination of EP and UA in human blood serum by DPV method. Good stability and durability in the determination of EP and UA were observed for the sensor. (C) 2014 Elsevier B.V. All rights reserved.
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页码：251 / 258
页数：8
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