Germline mutations predisposing to non-small cell lung cancer

被引：12

作者：

Clamon, Gerald H. ^{[1
]}

Bossler, Aaron D. ^{[2
]}

Abu Hejleh, Taher ^{[1
]}

Furqan, Muhammad ^{[1
]}

机构：

[1] Univ Iowa, Dept Internal Med, Coll Med, Univ Iowa Hosp, Iowa City, IA 52242 USA

[2] Univ Iowa Hosp, Dept Pathol, Iowa City, IA USA

来源：

FAMILIAL CANCER | 2015年 / 14卷 / 03期

关键词：

Germline mutations; Non-small cell lung cancer; Germline mutation; Lung cancer; SUSCEPTIBILITY LOCUS; GENETIC-VARIANTS; RISK; EGFR; PATIENT; V843I; RARE; MELANOMA; SNPS; ADENOCARCINOMAS;

D O I：

10.1007/s10689-015-9796-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer in multiple first degree relatives had previously been attributed to smoking and to inherited enzymes associated with increased activation of carcinogens in smoke. There was not clear agreement on the significance of the testing methods for lung cancer susceptibility. More recent studies have identified germline mutations associated with lung cancer even in the absence of smoking and other mutations with plausible explanations for their association with lung cancer caused by smoking. At this time, the clinical significance of the various germline mutations for screening and the implications for therapy are not certain. This review summarizes the currently identified germline mutations associated with lung cancer, but this growing area of research will very likely identify further significant mutations as well.

引用

页码：463 / 469

页数：7

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