Methods and clinical applications of targeted temperature management

Hypoxic/ischemic brain damage is well-known catastrophic injury. The specific treatment, so-called neuroprotective therapy, aims to prevent or diminish this havoc damage. However, approved neuroprotective therapy in clinical practice is limited. Targeted temperature management (TTM) shows the most promising neuroprotective therapy. Moreover, TTM is also useful for intracranial pressure (ICP) control. Many methods of TTM have been reported. TTM can apply to several clinical conditions associated with hypoxic/ischemic brain injury or elevated intracranial pressure.