Gastric dysmotility in Parkinson's disease is not caused by alterations of the gastric pacemaker cells

被引：15
作者：
Heimrich, Konstantin G. [1 ]
Jacob, Veit Y. P. [1 ]
Schaller, Denise [2 ]
Stallmach, Andreas [1 ]
Witte, Otto W. [2 ,3 ]
Prell, Tino [2 ,3 ]
机构：
[1] Jena Univ Hosp, Dept Gastroenterol, Jena, Germany
[2] Jena Univ Hosp, Dept Neurol, Jena, Germany
[3] Jena Univ Hosp, Ctr Hlth Ageing, Jena, Germany
来源：
NPJ PARKINSONS DISEASE | 2019年 / 5卷 / 1期
关键词：
VALIDATION; PHYSIOLOGY; SEVERITY; MEAL;
D O I：
10.1038/s41531-019-0087-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The enteric nervous system is involved in the pathology of Parkinson's disease and patients frequently have symptoms related to delayed gastric emptying. However, the pathophysiology of gastric dysmotility is yet not well understood. The objective of this study was to assess interdigestive gastric motility in Parkinson's disease. Using an electromagnetic capsule system, the dominant gastric contraction frequency (primary outcome measure) and the gastric transit time were assessed in 16 patients with Parkinson's disease and 15 young healthy controls after a fasting period of 8 h. Motor and non-motor symptoms were assessed using the Movement Disorder Society Unified Parkinson's Disease Rating Scale III (MDS-UPDRS III), the Non-Motor Symptoms Questionnaire (NMS-Quest), and Hoehn & Yahr staging. The Gastroparesis Cardinal Symptom Index was used to record symptoms related to delayed gastric emptying. In healthy controls and patients with Parkinson's disease, the dominant contraction frequency was 3.0 cpm indicating normal function of interstitial cells of Cajal. In patients with Parkinson's disease, the gastric transit time was longer than in younger controls (56 vs. 21 min). The dominant contraction frequency and gastric transit time did not correlate with age, disease duration, Hoehn & Yahr stage, levodopa equivalent daily dose, MDS-UPDRS III, NMS-Quest, and Gastroparesis Cardinal Symptom Index. Changes of gastric motility in Parkinson's disease are not caused by functional deficits of the gastric pacemaker cells, the interstitial cells of Cajal. Therefore, gastroparesis in Parkinson's disease can be attributed to disturbances in neurohumoral signals via the vagus nerve and myenteric plexus.
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页数：6
相关论文
共 29 条
[1]   Neuropathological basis of nonmotor manifestations of Parkinson's disease [J].
Adler, Charles H. ;
Beach, Thomas G. .
MOVEMENT DISORDERS, 2016, 31 (08) :1114-1119
[2]  
[Anonymous], BIOMEDIZINISCHE TECH
[3]   Aging and gastrointestinal neuromuscular function: insights from within and outside the gut [J].
Bitar, K. ;
Greenwood-Van Meerveld, B. ;
Saad, R. ;
Wiley, J. W. .
NEUROGASTROENTEROLOGY AND MOTILITY, 2011, 23 (06) :490-501
[4]   Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology [J].
Braak, H ;
de Vos, RAI ;
Bohl, J ;
Del Tredici, K .
NEUROSCIENCE LETTERS, 2006, 396 (01) :67-72
[5]  
Bradshaw L. Alan, 1997, American Journal of Physiology, V272, pG1159
[6]   Enteric neuro degeneration in ageing [J].
Camilleri, M. ;
Cowen, T. ;
Kochi, T. R. .
NEUROGASTROENTEROLOGY AND MOTILITY, 2008, 20 (03) :185-196
[7]  
Fasano A, 2015, LANCET NEUROL, V14, P625, DOI 10.1016/S1474-4422(15)00007-1
[8]   Movement disorder society-sponsored revision of the unified Parkinson's disease rating scale (MDS-UPDRS): Process, format, and clinimetric testing plan [J].
Goetz, Christopher G. ;
Fahn, Stanley ;
Martinez-Martin, Pablo ;
Poewe, Werner ;
Sampaio, Cristina ;
Stebbins, Glenn T. ;
Stern, Matthew B. ;
Tilley, Barbara C. ;
Dodel, Richard ;
Dubois, Bruno ;
Holloway, Robert ;
Jankovic, Joseph ;
Kulisevsky, Jaime ;
Lang, Anthony E. ;
Lees, Andrew ;
Leurgans, Sue ;
LeWitt, Peter A. ;
Nyenhuis, David ;
Olanow, C. Warren ;
Rascol, Olivier ;
Schrag, Anette ;
Teresi, Jeanne A. ;
van Hilten, Jacobus J. ;
LaPelle, Nancy .
MOVEMENT DISORDERS, 2007, 22 (01) :41-47
[9]   Predictors of gastric emptying in Parkinson's disease [J].
Goetze, O ;
Nikodem, AB ;
Wiezcorek, J ;
Banasch, M ;
Przuntek, H ;
Mueller, T ;
Schmidt, WE ;
Woitalla, D .
NEUROGASTROENTEROLOGY AND MOTILITY, 2006, 18 (05) :369-375
[10]   Impaired gastric emptying of a solid test meal in patients with Parkinson's disease using 13C-sodium octanoate breath test [J].
Goetze, O ;
Wieczorek, J ;
Mueller, T ;
Przuntek, H ;
Schmidt, WE ;
Woitalla, D .
NEUROSCIENCE LETTERS, 2005, 375 (03) :170-173
123