Asymmetric allylboration of aldehydes and ketones using 3,3′-disubstitutedbinaphthol-modified boronates

被引：160

作者：

Wu, TR ^{[1
]}

Shen, LX ^{[1
]}

Chong, JM ^{[1
]}

机构：

[1] Univ Waterloo, Dept Chem, Guelph Waterloo Ctr Grad Work Chem & Biochem, Waterloo, ON N2L 3G1, Canada

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 16期

关键词：

D O I：

10.1021/ol0490882

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Allylboronates derived from 3,3'-disubstituted 2,2'-binaphthols react with aldehydes and ketones to give the expected allylated products with up to >99:1 er. Highest selectivities were observed for aromatic ketones. The bis(trifluoromethyl) derivative is particularly outstanding in terms of reactivity, selectivity, and robustness.

引用

页码：2701 / 2704

页数：4

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