Isolation of Rat Olfactory Ensheathing Cells and Their Use in the Therapy of Posttraumatic Cysts of the Spinal Cord

被引：13
|
作者：
Stepanova, O. V. [1 ]
Voronova, D. D. [1 ,2 ]
Chadin, A. V. [1 ]
Valikhov, M. P. [1 ]
Abakumov, M. A. [2 ]
Reshetov, I. V. [3 ]
Chekhonin, V. P. [1 ,2 ]
机构：
[1] Minist Hlth Russian Federat, Dept Fundamental & Appl Neurobiol, VP Serbsky Natl Med Res Ctr Psychiat & Narcol, Moscow, Russia
[2] NI Pirogov Natl Res Med Univ, Minist Hlth Russian Federat, Med Biol Fac, Dept Med Nanobiotechnol, Moscow, Russia
[3] IM Sechenov First Moscow State Med Univ, Univ Clin Hosp 1, Minist Hlth Russian Federat, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 165卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
olfactory ensheathing cells; olfactory mucosa; cell therapy; spinal cord injuries; TRANSPLANTATION; REGENERATION; INJURY;
D O I：
10.1007/s10517-018-4114-x
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We evaluated the efficacy of rat olfactory ensheathing cells in the therapy of experimental cysts of the spinal cord. Improvement of the motor function of the hind limbs after transplantation of the olfactory ensheathing cells into the posttraumatic spinal cord cysts rats was found. We also determined the required number of cells for transplantation and demonstrated a neuroprotective effect of this dosage. For further clinical studies, autologous tissue-specific cell preparation of olfactory ensheathing cells has to be created. Cell therapy in combination surgical and pharmacological treatment will substantially improve the quality of life of patients with posttraumatic spinal cord cysts.
引用
收藏
页码：132 / 135
页数：4
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