Post-intubation subglottic stenosis: aetiology at the cellular and molecular level

被引：41

作者：

Dorris, Emma R. ^{[1
,2
]}

Russell, John ^{[3
]}

Murphy, Madeline ^{[1
,2
]}

机构：

[1] Our Ladys Childrens Hosp, Natl Childrens Res Ctr, Dublin, Ireland

[2] Univ Coll Dublin, Sch Med, Dublin, Ireland

[3] Childrens Hosp Ireland Crumlin, Dublin, Ireland

来源：

EUROPEAN RESPIRATORY REVIEW | 2021年 / 30卷 / 159期

关键词：

HEPATIC STELLATE CELLS; LARYNGOTRACHEAL STENOSIS; MITOMYCIN-C; MECHANICAL REGULATION; PULMONARY-FIBROSIS; AIRWAY INJURY; CANINE MODEL; RISK-FACTORS; IN-VIVO; HYPOXIA;

D O I：

10.1183/16000617.0218-2020

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Subglottic stenosis (SGS) is a narrowing of the airway just below the vocal cords. This narrowing typically consists of fibrotic scar tissue, which may be due to a variety of diseases. This review focuses on post-intubation (PI) SGS. SGS can result in partial or complete narrowing of the airway. This narrowing is caused by fibrosis and can cause serious breathing difficulties. It can occur in both adults and children. The pathogenesis of post-intubation SGS is not well understood; however, it is considered to be the product of an abnormal healing process. This review discusses how intubation can change the local micro-environment, leading to dysregulated tissue repair. We discuss how mucosal inflammation, local hypoxia and biomechanical stress associated with intubation can promote excess tissue deposition that occurs during the pathological process of SGS.

引用

页码：1 / 15

页数：15