Psoriasin (S100A7) up-regulation in oral squamous cell carcinoma and its relation to clinicopathologic features

被引：51

作者：

Kesting, Marco Rainer ^{[1
]}

Sudhoff, Holger ^{[2
]}

Hasler, Rafael Johannes ^{[1
]}

Nieberler, Markus ^{[1
]}

Pautke, Christoph ^{[1
]}

Wolff, Klaus-Dietrich ^{[1
]}

Wagenpfeil, Stefan ^{[3
]}

Al-Benna, Sammy ^{[4
]}

Jacobsen, Frank ^{[4
]}

Steinstraesser, Lars ^{[4
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Dept Oral & Maxillofacial Surg, D-81675 Munich, Germany

[2] Stadt Klinikum Bielefeld, Klinikum Mitte, Dept Otorhinolaryngol Head & Neck Surg, D-33604 Bielefeld, Germany

[3] Tech Univ Munich, Klinikum Rechts Isar, Dept Med Stat & Epidemiol, D-81675 Munich, Germany

[4] Ruhr Univ Bochum, BG Univ Klinikum Bergmannsheil, Burn Unit, Dept Plast Surg, D-44789 Bochum, Germany

来源：

ORAL ONCOLOGY | 2009年 / 45卷 / 08期

关键词：

S100A7; Psoriasin; Oral squamous cell carcinoma; Stage; Recurrence; Age; Clinicopathologic correlation; NECK-CANCER; EXPRESSION; METASTASIS; PROGRESSION; MARKER; CAVITY; HEAD; SKIN;

D O I：

10.1016/j.oraloncology.2008.11.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Proteomic analysis recently suggested aberrant psoriasin (S100A7) expression in oral squamous cell carcinoma (OSCC). In this study, OSCC specimens and matching normal oral tissues from 45 patients who had undergone ablative surgery were examined. Increased psoriasin expression at mRNA level was observed in OSCC samples by quantitative real-time RT-PCR (p = 0.015). Immunoflourescence analysis with psoriasin antibody confirmed these observations. Moreover, significantly increased mRNA ratios between malignant and normal samples were correlated with early UICC stage (p = 0.006), T1/T2 tumour classification (p = 0.043), absence of cervical lymph node metastasis (p = 0.027) and age under 65 (p = 0.009). Additionally, well-differentiated tumour tissues demonstrated a significantly higher psoriasin expression than moderate and poor differentiated carcinomas (p = 0.018). Based on this data, we conclude that psoriasin is a positive marker for oral cancerogenesis and early tumour progression. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：731 / 736

页数：6

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