Synthesis of New Conjugates of Modified Podophyllotoxin and Stavudine

被引：9

作者：

Chen, Shi-Wu ^{[1
,2
]}

Xiang, Rong ^{[1
,3
]}

Tian, Xuan ^{[2
]}

机构：

[1] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[3] Lanzhou Hosp Tradit Chinese Med Traumatocomium, Lanzhou 730000, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2009年 / 92卷 / 08期

关键词：

ANTI-HIV ACTIVITY; ANTIVIRAL ACTIVITY; AIDS AGENTS; DERIVATIVES; DISCOVERY; CONGENERS;

D O I：

10.1002/hlca.200900012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To find podophyllotoxin compounds with superior bioactivitiy and less toxicity, a series of novel conjugates of ring-A-modified 4-epipodophyllotoxin and stavudine with amino acids as spacers were synthesized, i.e., the N-[(2'.3'-didehydro-3'-deoxythymidin-5'-O-yl)carbonyl]-substituted L-amino acid rel- (3aR,4S,9R,9aR)-13,3a,4,9,9a-hexahydro-6,7-dimethoxy-1-oxo-9-(3,4,5-trimethoxyphenyl)naphtho[2,3-c]furan-4-yl esters 8a-8f.

引用

页码：1568 / 1574

页数：7

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