Physiology of energy homeostasis: Models, actors, challenges and the glucoadipostatic loop

被引:24
作者
Chapelot, Didier [1 ]
Charlot, Keyne [2 ]
机构
[1] Univ Paris 13, Ctr Rech Epidemiol & Stat, EREN, Inserm U1153,Inra U1125,Cnam, Bobigny, France
[2] Inst Rech Biomed Armees, Unite Physiol Exercices & Activites Condit Extrem, Dept Environnements Operationnels, Bretigny Sur Orge, France
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2019年 / 92卷
关键词
GLUCAGON-LIKE PEPTIDE-1; SYMPATHETIC-NERVOUS-SYSTEM; MESOLIMBIC DOPAMINE SYSTEM; VENTRAL TEGMENTAL AREA; DIET-INDUCED OBESITY; REDUCES FOOD-INTAKE; EXPERIMENTAL WEIGHT PERTURBATION; HYPOTHALAMIC ARCUATE NUCLEUS; ADIPOSE-TISSUE LIPOLYSIS; MUSCLE WORK EFFICIENCY;
D O I
10.1016/j.metabol.2018.11.012
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of this review is to discuss the physiology of energy homeostasis (EH), which is a debated concept. Thus, we will see that the set-point theory is highly challenged and that other models integrating an anticipative component, such as energy allostasis, seem more relevant to experimental reports and life preservation. Moreover, the current obesity epidemic suggests that EH is poorly efficient in the modern human dietary environment. Non-homeostatic phenomena linked to hedonism and reward seem to profoundly impair EH. In this review, the apparent failed homeostatic responses to energy challenges such as exercise, cafeteria diet, overfeeding and diet-induced weight loss, as well as their putative determinants, are analyzed to highlight the mechanisms of EH. Then, the hormonal, neuronal, and metabolic factors of energy intake or energy expenditure are briefly presented. Last, this review focuses on the contributions of two of the most pivotal and often overlooked determinants of EH: the availability of endogenous energy and the pattern of energy intake. A glucoadipostatic loop model is finally proposed to link energy stored in adipose tissue to EH through changes in eating behavior via leptin and sympathetic nervous system activity. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:11 / 25
页数:15
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