Controlling elements in replication of the human immunodeficiency virus type 1

被引:0
作者
Li, XG [1 ]
Quan, YD [1 ]
Wainberg, MA [1 ]
机构
[1] JEWISH GEN HOSP,MCGILL AIDS CTR,MONTREAL,PQ H3T 1E2,CANADA
关键词
HIV-1; reverse transcriptase; pathogenesis;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have reviewed the genetic structure of HIV-1 from the perspective of understanding viral and cellular regulatory factors that affect viral replication. Comparisons are drawn, as appropriate, with other human retroviruses, such as HIV-2, in regard to our understanding of pathogenesis. The synthesis of viral protein and the manner in which viral assembly takes place is also discussed.
引用
收藏
页码:443 / 454
页数:12
相关论文
共 85 条
[31]   REV ACTIVATES EXPRESSION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VIF-GENE AND VPR-GENE PRODUCTS [J].
GARRETT, ED ;
TILEY, LS ;
CULLEN, BR .
JOURNAL OF VIROLOGY, 1991, 65 (03) :1653-1657
[32]   MORPHOGENESIS AND MORPHOLOGY OF HIV - STRUCTURE-FUNCTION RELATIONS [J].
GELDERBLOM, HR ;
OZEL, M ;
PAULI, G .
ARCHIVES OF VIROLOGY, 1989, 106 (1-2) :1-13
[33]   DETAILED MODEL OF REVERSE TRANSCRIPTION AND TESTS OF CRUCIAL ASPECTS [J].
GILBOA, E ;
MITRA, SW ;
GOFF, S ;
BALTIMORE, D .
CELL, 1979, 18 (01) :93-100
[34]  
GOFF SP, 1992, ANNU REV GENET, V26, P527, DOI 10.1146/annurev.ge.26.120192.002523
[35]  
GOFF SP, 1990, J ACQ IMMUN DEF SYND, V3, P817
[36]   POINT MUTANTS OF MOLONEY MURINE LEUKEMIA-VIRUS THAT FAIL TO PACKAGE VIRAL-RNA - EVIDENCE FOR SPECIFIC RNA RECOGNITION BY A ZINC FINGER-LIKE PROTEIN-SEQUENCE [J].
GORELICK, RJ ;
HENDERSON, LE ;
HANSER, JP ;
REIN, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (22) :8420-8424
[37]   ROLE OF CAPSID PRECURSOR PROCESSING AND MYRISTOYLATION IN MORPHOGENESIS AND INFECTIVITY OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 [J].
GOTTLINGER, HG ;
SODROSKI, JG ;
HASELTINE, WA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) :5781-5785
[38]   EFFECT OF MUTATIONS AFFECTING THE P6 GAG PROTEIN ON HUMAN-IMMUNODEFICIENCY-VIRUS PARTICLE RELEASE [J].
GOTTLINGER, HG ;
DORFMAN, T ;
SODROSKI, JG ;
HASELTINE, WA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (08) :3195-3199
[39]   MOLECULAR-BIOLOGY OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].
HASELTINE, WA .
FASEB JOURNAL, 1991, 5 (10) :2349-2360
[40]   HIV-1 REGULATOR OF VIRION EXPRESSION (REV) PROTEIN BINDS TO AN RNA STEM-LOOP STRUCTURE LOCATED WITHIN THE REV RESPONSE ELEMENT REGION [J].
HEAPHY, S ;
DINGWALL, C ;
ERNBERG, I ;
GAIT, MJ ;
GREEN, SM ;
KARN, J ;
LOWE, AD ;
SINGH, M ;
SKINNER, MA .
CELL, 1990, 60 (04) :685-693