The Association of Targeted Gut Microbiota with Body Composition in Type 2 Diabetes Mellitus

被引：31

作者：

Hung, Wei-Chun ^{[1
]}

Hung, Wei-Wen ^{[2
]}

Tsai, Hui-Ju ^{[3
]}

Chang, Chen-Chia ^{[1
]}

Chiu, Yi-Wen ^{[4
,5
]}

Hwang, Shang-Jyh ^{[4
,5
]}

Kuo, Mei-Chuan ^{[4
,5
]}

Chen, Szu-Chia ^{[4
,5
,6
,7
]}

Dai, Chia-Yen ^{[6
,8
]}

Tsai, Yi-Chun ^{[4
,5
,6
,9
,10
]}

机构：

[1] Kaohsiung Med Univ, Coll Med, Dept Microbiol & Immunol, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Family Med, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan

[5] Kaohsiung Med Univ, Coll Med, Fac Renal Care, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung, Taiwan

[7] Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Internal Med, Kaohsiung, Taiwan

[8] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Hepatobiliary, Kaohsiung, Taiwan

[9] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Gen Med, Kaohsiung, Taiwan

[10] Kaohsiung Med Univ, Cohort Res Ctr, Kaohsiung, Taiwan

来源：

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2021年 / 18卷 / 02期

关键词：

Type 2 diabetes mellitus; gut microbiota; lean tissue index; Firmicutes; Bacteroidetes; MUSCLE MASS; METFORMIN; OBESITY; MALNUTRITION; METAGENOME; STRENGTH; FLUID;

D O I：

10.7150/ijms.51164

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The association between body composition and gut microbiota in type 2 diabetes mellitus (DM) remains unknown. To elucidate the correlation of body composition and gut microbiota, we conducted a clinical study to enroll 179 patients with type 2 DM. Body composition of lean tissue index (LTI) and fat tissue index was measured by Body Composition Monitor. Eight pairs of 16S rRNA gene primers specific to Firmicutes, Bacteroidetes, the Clostridium leptum group, Bacteroides, Bifidobacterium, Akkermansia muciniphila, Escherichia coli, and Faecalibacterium prausnitzii were used to measure their abundance by quantitative polymerase chain reaction. The results showed that type 2 DM with higher abundance of phylum Firmicutes and a higher ratio of phyla Firmicutes to Bacteroidetes (phyla F/B ratio) had higher LTI. This significant correlation between phyla F/B ratio and LTI was especially evident in type 2 DM with high body mass index, and independent of glycemic control or dipeptidyl peptidase-4 inhibitor usage. In conclusion, our study demonstrated the positive association of LTI with the abundance of phylum Firmicutes and the phyla F/B ratio in type 2 DM.

引用

页码：511 / 519

页数：9

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