Promethazine Potentiometric Membrane Sensor for Promethazine Hydrochloride Pharmaceutical Analysis; Computational Study

被引：0
|
作者：
Ganjali, Mohammad Reza [1 ]
Vesimohammadi, Bahareh [1 ]
Riahi, Siavash [1 ,2 ]
Norouzi, Parviz [1 ]
机构：
[1] Univ Tehran, Fac Chem, Ctr Excellence Electrochem, Tehran, Iran
[2] Univ Tehran, Fac Engn, Inst Petr Engn, Tehran, Iran
来源：
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE | 2009年 / 4卷 / 05期
关键词：
Potentiometric sensor; PVC membrane; Promethazine hydrochloride; Computational Chemistry; Chemometrics; Density functional based tight binding (DFTB); LANTHANIDE RECOGNITION; USEFUL DEVICE; IONS; FORMULATION; MICROSENSOR; MOLECULES; ELECTRODE; URINE; SELECTIVITY; PREDICTION;
D O I：
暂无
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
Promethazine (PM) is an antihistamine and antiemetic medication. In this study, a potentiometric liquid membrane sensor for simple and fast determination of promethazine hydrochloride in pharmaceutical formulation and urine was constructed. For the membrane preparation, PM-tetraphenylborate complexes were employed as electroactive material in the membrane. The wide linear range (10(-5)-10(-2) mol L(-1)), low detection limit (1.0x10(-5) mol L(-1)), and fast response time (similar to 5s) are characterizations of the proposed sensors. Validation of the method shows suitability of the sensors for applies in the quality control analysis of promethazine hydrochloride in pharmaceutical formulation and urine.
引用
收藏
页码：740 / 754
页数：15
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