Formal synthesis of (-) anisomycin via organocatalysis

被引：13

作者：

Chouthaiwale, Pandurang V. ^{[1
]}

Kotkar, Shriram P. ^{[1
]}

Sudalai, Arumugam ^{[1
]}

机构：

[1] Natl Chem Lab, Chem Engn & Proc Dev Div, Pashan Rd, Pune 411008, Maharashtra, India

来源：

ARKIVOC | 2009年

关键词：

alpha-amination; alpha-aminoxylation; anisomycin; olefination; proline; STEREOSELECTIVE NUCLEOPHILIC-SUBSTITUTION; ENANTIOSELECTIVE SYNTHESIS; (-)-ANISOMYCIN; OLEFINATION; ALDEHYDES;

D O I：

10.3998/ark.5550190.0010.210

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient formal synthesis of (-) anisomycin (1), a potent antibiotic agent, has been achieved in good yields and excellent diastereoselectivity. The key steps are proline-catalyzed sequential alpha-amination or alpha-aminoxylation of aldehyde 2 followed by tandem Horner-Wadsworth-Emmons olefination.

引用

页码：88 / 94

页数：7

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