Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats

被引：91

作者：

Ince, Sinan ^{[1
]}

Kucukkurt, Ismail ^{[2
]}

Demirel, Hasan Huseyin ^{[3
]}

Acaroz, Damla Arslan ^{[2
]}

Akbel, Erten ^{[4
]}

Cigerci, Ibrahim Hakki ^{[5
]}

机构：

[1] Afyon Kocatepe Univ, Fac Vet Med, Dept Pharmacol & Toxicol, TR-03030 Afyon, Turkey

[2] Afyon Kocatepe Univ, Fac Vet Med, Dept Biochem, TR-03030 Afyon, Turkey

[3] Afyon Kocatepe Univ, Fac Vet Med, Dept Pathol, TR-03030 Afyon, Turkey

[4] Usak Univ, Usak Hlth Training Sch, TR-64100 Usak, Turkey

[5] Afyon Kocatepe Univ, Fac Sci & Arts, Dept Biol, TR-03030 Afyon, Turkey

来源：

CHEMOSPHERE | 2014年 / 108卷

关键词：

Boron; Cyclophosphamide; Genotoxicity; Lipid peroxidation; Rat; INDUCED OXIDATIVE STRESS; BORIC-ACID; DNA-DAMAGE; STRAND BREAKS; NITRIC-OXIDE; DIETARY; SUPPLEMENTATION; BLOOD; CHEMOTHERAPY; CARCINOMA;

D O I：

10.1016/j.chemosphere.2014.01.038

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The aim of the present study was to evaluate the possible protective effect of boron (B) on cyclophosphamide (CYC) induced oxidative stress in rats. Totally, thirty Wistar albino male rats were fed standard rodent diet and divided into 5 equal groups: physiological saline was given intraperitoneally (i.p.) to the control group (vehicle treated), to the second group only 75 mg kg(-1) CYC was given i.p. on the 14th d, and boron was administered (5, 10, and 20 mg kg(-1), i.p.) to the other groups for 14 d and CYC (75 mg kg(-1), i.p.) on the 14th d. CYC caused increase of malondialdehyde and decrease of glutathione levels, decrease of superoxide dismutase activities in erythrocyte and tissues, decrease of erythrocyte, heart, lung, and brain catalase, and plasma antioxidant activities. Also, CYC treatment caused to DNA damage in mononuclear leukocytes. Moreover. B exhibited protective action against the CYC-induced histopathological changes in tissues. However, treatment of B decreased severity of CYC-induced lipid peroxidation and genotoxicity on tissues. In conclusion, B has ameliorative effects against CYC-induced lipid peroxidation and genotoxicity by enhancing antioxidant defence mechanism in rat. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：197 / 204

页数：6

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