Multi-membrane hydrogel fabricated by facile dynamic self-assembly

Multi-membrane hydrogels are newly promising carriers in biomedical fields. We fabricate alginate-based onion-like multi-membrane hydrogels starting from a template gel-core to shells through a dynamic self-assembly method, and investigate the influence of various factors on the formation of the complex system in detail. By precisely controlling the process of preparation, multilayered hydrogels of different shapes either with or without defined internal space between separated layers can be prepared. And a pulse-like delivery of macromolecule has been achieved by this architecture.