A genetic analysis of brain volumes and IQ in children

被引:31
|
作者
van Leeuwen, Marieke [1 ]
Peper, Jiska S. [2 ]
van den Berg, Stephanie M. [3 ]
Brouwer, Rachel M. [2 ]
Pol, Hilleke E. Hulshoff [2 ]
Kahn, Rene S. [2 ]
Boomsma, Dorret I. [1 ]
机构
[1] Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands
[2] Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Psychiat, NL-3584 CX Utrecht, Netherlands
[3] Univ Utrecht, Fac Vet Med, Utrecht, Netherlands
关键词
White matter volume; Gray matter volume; Intelligence; Twin study; Children; COGNITIVE-ABILITY; WHITE-MATTER; SNAP-25; GENE; MR-IMAGES; INTELLIGENCE; CHILDHOOD; SIZE; ASSOCIATION; FAMILY; GRAY;
D O I
10.1016/j.intell.2008.10.005
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
In a population-based sample of 112 nine-year old twin pairs, we investigated the association among total brain volume, gray matter and white matter volume, intelligence as assessed by the Raven IQ test, verbal comprehension. perceptual organization and perceptual speed as assessed by the Wechsler Intelligence Scale for Children-III. Phenotypic correlations between the brain volumes and intelligence traits ranged between .20 and .33. Processing speed and brain volume did not correlate. The relation between brain volume and intelligence was entirely explained by a common set of genes influencing both sets of phenotypes. Crown Copyright (C) 2008 Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:181 / 191
页数:11
相关论文
共 50 条
  • [21] Full scale IQ (FSIQ) changes in children treated with whole brain and partial brain irradiation - A review and analysis
    Fuss, M
    Poljanc, K
    Hug, EB
    STRAHLENTHERAPIE UND ONKOLOGIE, 2000, 176 (12) : 573 - 581
  • [22] Effects of Gestational Age and Birth Weight on Brain Volumes in Healthy 9 Year-Old Children
    van Soelen, Inge L. C.
    Brouwer, Rachel M.
    Peper, Jiska S.
    van Beijsterveldt, Toos C. E. M.
    van Leeuwen, Marieke
    de Vries, Linda S.
    Kahn, Rene S.
    Pol, Hilleke E. Hulshoff
    Boomsma, Dorret I.
    JOURNAL OF PEDIATRICS, 2010, 156 (06) : 896 - 901
  • [23] Associations between education and brain structure at age 73 years, adjusted for age 11 IQ
    Cox, Simon R.
    Dickie, David Alexander
    Ritchie, Stuart J.
    Karama, Sherif
    Pattie, Alison
    Royle, Natalie A.
    Corley, Janie
    Aribisala, Benjamin S.
    Hernandez, Maria Valdes
    Maniega, Susana Munoz
    Starr, John M.
    Bastin, Mark E.
    Evans, Alan C.
    Wardlaw, Joanna M.
    Deary, Ian J.
    NEUROLOGY, 2016, 87 (17) : 1820 - 1826
  • [24] Underlying neurological dysfunction in children with language, speech or learning difficulties and a verbal IQ - performance IQ discrepancy
    Meulemans, J.
    Goeleven, A.
    Zink, I.
    Loyez, L.
    Lagae, L.
    Debruyne, F.
    B-ENT, 2012, 8 (02): : 71 - 76
  • [25] Genetic Structure of IQ, Phonemic Decoding Skill, and Academic Achievement
    Lazaroo, Nikita K.
    Bates, Timothy C.
    Hansell, Narelle K.
    Wright, Margaret J.
    Martin, Nicholas G.
    Luciano, Michelle
    FRONTIERS IN GENETICS, 2019, 10
  • [26] Genetic priming of a proinflammatory profile predicts low IQ in octogenarians
    Krabbe, K. S.
    Mortensen, E. L.
    Avlund, K.
    Pilegaard, H.
    Christiansen, L.
    Pedersen, A. N.
    Schroll, M.
    Jorgensen, T.
    Pedersen, B. K.
    Bruunsgaard, H.
    NEUROBIOLOGY OF AGING, 2009, 30 (05) : 769 - 781
  • [27] Size at birth predicts later brain volumes
    Nivins, Samson
    Kennedy, Eleanor
    McKinlay, Christopher
    Thompson, Benjamin
    Harding, Jane E.
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [28] COMT Val158Met Modulates Association Between Brain White Matter Architecture and IQ
    Li, Jun
    Yu, Chunshui
    Li, Yonghui
    Liu, Bing
    Liu, Yong
    Shu, Ni
    Song, Ming
    Zhou, Yuan
    Zhu, Wanlin
    Li, Kuncheng
    Jiangi, Tianzi
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2009, 150B (03) : 375 - 380
  • [29] Gray matter volumes and cognitive ability in the epileptogenic brain malformation of periventricular nodular heterotopia
    Walker, Linsey M.
    Katzir, Tami
    Liu, Tianming
    Ly, Jenny
    Corriveau, Kathleen
    Barzillai, Mirit
    Chu, Felicia
    O'Connor, Margaret G.
    Hackney, David B.
    Chang, Bernard S.
    EPILEPSY & BEHAVIOR, 2009, 15 (04) : 456 - 460
  • [30] Total brain, cortical, and white matter volumes in children previously treated with glucocorticoids
    Holm, Sara K.
    Madsen, Kathrine S.
    Vestergaard, Martin
    Paulson, Olaf B.
    Uldall, Peter
    Siebner, Hartwig R.
    Born, Alfred P.
    Baare, William F. C.
    PEDIATRIC RESEARCH, 2018, 83 (04) : 804 - 812