Biological and Hypoglycemic Effects of a Polyherbal Extract on Alloxanized Diabetic Rats

被引:5
|
作者
Gardezi, Syed Naseer Hussain [1 ]
Akhtar, Muhammad Tahir [1 ]
Qadir, Rahman [1 ]
Mustaqeem, Muhammad [1 ]
Batool, Sajida [1 ]
Siddique, Abu Bakar [1 ]
Alhumade, Hesham [3 ,4 ]
Tahir, Mudassir Hussain [5 ]
Saadia, Mubshara [2 ]
机构
[1] Univ Sargodha, Inst Chem, Sargodha 40100, Pakistan
[2] Govt Coll Women Univ, Dept Biochem, Faisalabad 38000, Pakistan
[3] King Abdulaziz Univ, KA CARE Energy Res & Innovat Ctr, Jeddah 21589, Saudi Arabia
[4] King Abdulaziz Univ, Fac Engn, Dept Chem & Mat Engn, Jeddah 21589, Saudi Arabia
[5] Kyoto Univ, Grad Sch Energy Sci, Kyoto 6068501, Japan
来源
ACS OMEGA | 2022年 / 7卷 / 51期
关键词
NIGELLA-SATIVA; FORMULATION;
D O I
10.1021/acsomega.2c05363
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The current study investigates the antioxidant, antidiabetic, hepatoprotective, and nephroprotective potentials of a polyherbal mixture containing the methanolic extracts of seeds from Nigella sativa, Cicer arietinum, Silybum marianum, and Citrullus colocynthis and the rhizome of Zingiber officinale. The polyherbal extract (PHE) showed significant total phenolic contents (187.17 GAE/g), ferric reducing power (28%), and radical-scavenging activity (86.16%). The PHE also showed a substantial hypoglycemic effect in alloxan-induced diabetic rats by reducing the blood glucose level of the PHE-treated rats (-48.64%) and increasing the insulin level (107.5%) as compared with the diabetic control group. Likewise, an increase in high-density lipoprotein (HDL) contents (22.95%) with an associated decrease in low-density lipoprotein (LDL) levels (-43.93%) was also noted. A significant decrease in serum levels of liver marker enzymes, e.g., SGPT (-36%), SGOT (-31%), and serum ALP (-12%), was also observed as compared with the standard drug-treated group. Based on the findings of the study, it may be suggested that PHE helps ameliorate the severity of diabetes as a herbal remedy and might be employed in nutra-pharmaceuticals, replacing synthetic antidiabetic compounds.
引用
收藏
页码:47755 / 47763
页数:9
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