Albumin-bilirubin score indicates liver fibrosis staging and prognosis in patients with chronic hepatitis C

被引：42

作者：

Fujita, Koji ^{[1
]}

Oura, Kyoko ^{[1
]}

Yoneyama, Hirohito ^{[1
]}

Shi, Tingting ^{[1
]}

Takuma, Kei ^{[1
]}

Nakahara, Mai ^{[1
]}

Tadokoro, Tomoko ^{[1
]}

Nomura, Takako ^{[1
]}

Morishita, Asahiro ^{[1
]}

Tsutsui, Kunihiko ^{[1
]}

Himoto, Takashi ^{[2
]}

Masaki, Tsutomu ^{[1
]}

机构：

[1] Kagawa Univ, Fac Med, Dept Gastroenterol & Neurol, Miki, Kagawa, Japan

[2] Kagawa Prefectural Univ Hlth Sci, Dept Med Technol, Takamatsu, Kagawa, Japan

来源：

HEPATOLOGY RESEARCH | 2019年 / 49卷 / 07期

关键词：

hepatitis C; chronic; hepatocellular carcinoma; liver cirrhosis; prognosis; SIMPLE NONINVASIVE INDEX; HEPATOCELLULAR-CARCINOMA; PLUS RIBAVIRIN; BIOPSY; PEGINTERFERON; ELASTOGRAPHY; INFECTION; CIRRHOSIS; DISEASE; MARKERS;

D O I：

10.1111/hepr.13333

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Aim Albumin-bilirubin (ALBI) grade was investigated to predict prognosis of patients with cirrhosis. It was defined using the ALBI score calculated based on serum total bilirubin and albumin, which represent liver function. The diagnostic accuracy for liver fibrosis staging in patients with chronic hepatitis using the ALBI score has not been investigated well. This study aimed to evaluate the diagnostic abilities of the ALBI score for liver fibrosis staging in chronic hepatitis and cirrhosis in Japanese patients with hepatitis C virus (HCV) infection. Methods Japanese patients with HCV infection who underwent liver biopsy examinations were enrolled in a retrospective study. Fibrosis staging and activity grading were assessed using the modified METAVIR score. The ALBI score was calculated according to the following equation: Log10 total bilirubin (mu mol/L) x 0.66 + albumin (g/L) x (-0.085). Results A total of 382 patients were enrolled in this study. The ALBI score differentiated fibrosis stage 4 from 3 and stage 3 from 2 (P < 0.05). When an ALBI score of -2.125 was adopted as a cut-off value, the sensitivity and specificity were 73.2% and 87.1%, respectively, with a positive likelihood ratio of 5.67 to differentiate stage 4 from stages 1-3. Kaplan-Meier analysis showed that smaller ALBI scores at baseline correlated with better hepatocellular carcinoma (HCC)-free and overall survival (P < 0.05). Conclusions The ALBI score indicates liver fibrosis staging in Japanese patients with HCV infection. Furthermore, smaller ALBI scores predict better HCC-free survival and overall survival. The ALBI score has the potential to expand its application from cirrhosis to chronic hepatitis.

引用

页码：731 / 742

页数：12

共 39 条

[1] DIAGNOSTIC-TESTS-3 - RECEIVER OPERATING CHARACTERISTIC PLOTS .7. [J].