The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity

被引：55
作者：
Wallner, Stephanie [1 ]
Peters, Sebastian [2 ]
Pitzer, Claudia [3 ]
Resch, Herbert [1 ,4 ]
Bogdahn, Ulrich [2 ]
Schneider, Armin [5 ]
机构：
[1] Paracelsus Med Univ Salzburg, Spinal Cord Injury & Tissue Regenerat Ctr Salzbur, Dept Traumatol & Sports Injuries, Strubergasse 22, A-5020 Salzburg, Austria
[2] Univ Hosp Regensburg, Dept Neurol, Regensburg, Germany
[3] Ruprecht Karls Univ Heidelberg, Interdisciplinary Neurobehav Core, Heidelberg, Germany
[4] Paracelsus Med Univ Salzburg, Univ Clin Traumatol & Sports Injuries Salzburg, Salzburg, Austria
[5] SYGNIS Biosci GmbH, Heidelberg, Germany
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2015年 / 3卷
关键词：
SCI; ALS; G-CSF; neurogenesis; arteriogenesis; angiogenesis; neuroregeneration; plasticity;
D O I：
10.3389/fcell.2015.00048
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also plays a role in the brain as a growth factor for neurons and neural stem cells, and as a factor involved in the plasticity of the vasculature. We review and discuss these dual properties in view of the neuroregenerative potential of this growth factor.
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页数：13
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