The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity

被引：54

作者：

Wallner, Stephanie ^{[1
]}

Peters, Sebastian ^{[2
]}

Pitzer, Claudia ^{[3
]}

Resch, Herbert ^{[1
,4
]}

Bogdahn, Ulrich ^{[2
]}

Schneider, Armin ^{[5
]}

机构：

[1] Paracelsus Med Univ Salzburg, Spinal Cord Injury & Tissue Regenerat Ctr Salzbur, Dept Traumatol & Sports Injuries, Strubergasse 22, A-5020 Salzburg, Austria

[2] Univ Hosp Regensburg, Dept Neurol, Regensburg, Germany

[3] Ruprecht Karls Univ Heidelberg, Interdisciplinary Neurobehav Core, Heidelberg, Germany

[4] Paracelsus Med Univ Salzburg, Univ Clin Traumatol & Sports Injuries Salzburg, Salzburg, Austria

[5] SYGNIS Biosci GmbH, Heidelberg, Germany

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2015年 / 3卷

关键词：

SCI; ALS; G-CSF; neurogenesis; arteriogenesis; angiogenesis; neuroregeneration; plasticity;

D O I：

10.3389/fcell.2015.00048

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also plays a role in the brain as a growth factor for neurons and neural stem cells, and as a factor involved in the plasticity of the vasculature. We review and discuss these dual properties in view of the neuroregenerative potential of this growth factor.

引用

页数：13

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