Selectively Oxidative C(sp2)-H/C(sp3)-H Cross-Coupling of Benzamides with Amides by Nickel Catalysis

被引：11

作者：

Lv, Ningning ^{[1
]}

Yu, Shuling ^{[2
]}

Hong, Chao ^{[2
]}

Han, De-Man ^{[3
]}

Zhang, Yuhong ^{[2
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

[2] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

[3] Taizhou Univ, Dept Chem, Jiaojiang 318000, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 23期

关键词：

C-H BOND; C(SP(3))-H BONDS; ARENES; C(SP(2))-H; ALKENES; FUNCTIONALIZATION; METHYLATION; ACTIVATION; AMINATION; INDOLES;

D O I：

10.1021/acs.orglett.0c03535

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The oxidative cross-coupling between the alpha-C(sp(3))-H bond of amide in DMAc and the inert ortho-C(sp(2))-H bond of benzamides is achieved for the first time by nickel catalysis, with the assistance of 8-aminoquinolyi group in the presence of a silver oxidant. Notably, the selectivity of conversion can be perfectly controlled by modulating the oxidant additives, and the products from the coupling of the C(sp(3))-H bond adjacent to nitrogen of amides with benzamides are approached through the use of peroxide.

引用

页码：9308 / 9312

页数：5

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